A novel manual rotating fluid control mechanism in a microfluidic device with a finger-actuated pump for dual-mode sweat sampling.

IF 6.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Lab on a Chip Pub Date : 2025-04-03 DOI:10.1039/d5lc00171d
Mohamed Ishag Hassan Gama, Saminu Abdullahi, Marwa Omer Mohammed Omer, Zhu Yang, Xuzhong Wang, Yousuf Babiker M Osman, Yuhang Liu, Jingzhen Li, Yingtian Li, Xing Gao, Zedong Nie
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引用次数: 0

Abstract

Wearable sweat analysis using microfluidics offers a non-invasive approach for real-time health monitoring, with applications in chronic disease management, athletic performance optimization, and early-stage condition detection. However, most existing wearable sweat microfluidic devices are limited to single-mode operation either real-time or on-demand sampling and often lack precise control over sample volume, which compromises analytical accuracy and utility. To address these limitations, we present a novel wearable microfluidic device featuring a manual rotating fluid control mechanism and a finger-actuated pump for dual-mode sweat sampling. The rotational control mechanism directs sweat either into detection chambers for volume-independent sensor reactions or through the finger-actuated pump for precise volume control. The pump incorporates a dedicated collection chamber, enabling sweat accumulation and controlled delivery in a single actuation, ensuring reproducible sample volumes and facilitating on-demand analysis when required. Additionally, the device integrates two reaction chambers for simultaneous dual biomarker detection. Performance validation during a 40 minute exercise session, using a colorimetric glucose assay, demonstrated reliable sweat sampling and on-demand biochemical analysis. These results highlight the device's potential as a practical tool for personalized health monitoring and field applications.

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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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