Reproductive Outcomes of Women With Endometrial Fluid During IVF-ICSI Treatment: A Single-Center Experience

IF 2.4 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2025-04-04 DOI:10.1111/aji.70072

Burcu Tas Uzun, Emine Sen Bicak, Erinc Tekin, Hasan Ali Inal, Mete Caglar

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引用次数: 0

Abstract

Objective

To retrospectively evaluate whether endometrial fluid detected at transvaginal ultrasonography on the third day of the menstrual cycle in infertile patients undergoing in vitro fertilization/intracytoplasmic sperm injection–embryo transfer (IVF-ICSI/ET) affects pregnancy outcomes.

Methods

A total of 148 patients who had undergone IVF-ICSI between 2010 and 2017 were included in this study. The participants were stratified according to the presence of endometrial fluid: Group 1 (control; n = 74) consisted of women without endometrial fluid and Group 2 (study; n = 74) of those with endometrial fluid. Baseline sociodemographic characteristics and reproductive outcomes were compared between the groups.

Results

No difference was found between the groups in terms of age, body mass index, smoking rates, duration of infertility, etiology of infertility, baseline follicle-stimulating hormone, luteinizing hormone, estradiol, thyroid-stimulating hormone, and prolactin levels, duration of stimulation, stimulation protocol, antral follicle counts, total gonadotropin doses, peak E₂ and progesterone levels on the day of human chorionic gonadotropin (hCG) administration, or endometrial thickness at hCG administration and the day of transfer (p > 0.05). The number of oocytes retrieved, metaphase II oocytes, two pronuclei, fertilization rates, and the rates of Grade I embryos per woman, as well as pronucleus counts, were comparable between the groups (p > 0.05). However, the clinical pregnancy rate (CPR) (47.3% vs. 31.1%) and live birth rate (LBR) (41.9% vs. 24.3%) were both significantly lower in women with endometrial fluid compared to the control group (p < 0.05).

Conclusion

This retrospective cohort study shows that the women with endometrial fluid in their IVF-ICSI/ET cycles exhibited lower CPR and LBR. Further prospective studies are needed to confirm the validity of our results.

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IVF-ICSI治疗期间子宫内膜积液妇女的生殖结局：单中心经验

目的回顾性评价体外受精/卵胞浆内单精子注射-胚胎移植（IVF-ICSI/ET）的不孕症患者月经周期第3天阴道超声检查子宫内膜液对妊娠结局的影响。方法选取2010 ~ 2017年接受IVF-ICSI治疗的148例患者。根据子宫内膜液的存在将参与者分层：1组(对照组；n = 74)包括无子宫内膜积液的妇女和第二组(研究；N = 74)。比较各组之间的基线社会人口学特征和生殖结果。结果两组在年龄、体重指数、吸烟率、不孕持续时间、不孕病因、促卵泡激素、黄体生成素、雌二醇、促甲状腺激素、催乳素基线水平、刺激持续时间、刺激方案、窦卵泡计数、促性腺激素总剂量、促性腺激素（hCG）给药当日E2和孕酮峰值水平等方面均无差异。或hCG给药时子宫内膜厚度及移植当日(p >；0.05)。两组之间的卵母细胞数量、中期卵母细胞、两个原核、受精率、每个妇女的I级胚胎率以及原核计数具有可比性(p >；0.05)。然而，与对照组相比，子宫内膜积液组的临床妊娠率（CPR）（47.3%对31.1%）和活产率（LBR）（41.9%对24.3%）均显著降低(p <；0.05)。结论：本回顾性队列研究表明，在IVF-ICSI/ET周期中存在子宫内膜积液的妇女表现出较低的CPR和LBR。需要进一步的前瞻性研究来证实我们结果的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.