Organ-On-A-Chip Platforms Created Through Buckled Microchannels of Porous Hydrogel Films (Adv. Mater. Technol. 7/2025)

Abstract

Organ-on-a-Chip Platforms

In article number 2401468, Riku Takahashi and co-workers present a method for fabricating permeable microchannels by integrating hydrogel porosification with thin-film shape control. This approach enhances permeability while preserving the excellent mechanical properties of synthetic polymers. The developed microchannel system supports vascular endothelial cell culture, functioning as a vessel-on-a-chip platform for barrier function assessment, diverse channel fabrication, and co-culture system development.