Dual-wave hybrid acoustofluidic centrifuge for rapid enrichment of micro- and nanoscale biological particles

IF 4.1 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-03-28 DOI:10.1016/j.sna.2025.116495

Shaoshuai Han , Tongfei Wu , Honghao Li , He Li , Xin Yang , Ning Li , Tangcheng Huang , Jun Ren , Zhenlin Wu

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引用次数: 0

Abstract

Rapid enrichment of micro- and nanoscale biological particles in microliter volumes presents substantial potential for applications in biosensing, disease diagnosis, and therapeutic interventions. Herein, a dual-wave hybrid acoustofluidic centrifuge (DHAC) technique is presented, which generates both Rayleigh and Shear Horizontal waves by optimizing the angle between the electrode and the reference flat of the piezoelectric substrate. The dual waves generate a complex acoustic field within the droplet, enabling the effective concentration of nanoparticles and various biological particles. The DHAC efficiently concentrates micro- and nanoscale particles ranging from 50 nm to 1

μ

m within a 150

μ

L sample in 120 s, operating at 34.8 MHz with a chip power of 31 dBm, achieving an enrichment rate approximately 3.6 times higher than that of a single-wave acoustofluidic centrifuge. Furthermore, the cell viability of 293-F cells after 1 h of acoustic excitation in the DHAC device exceeded 90%, further confirming its high biocompatibility. This technology offers significant potential as an advanced tool for precise biochemical analysis and effective disease diagnostics.

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...