Preparation, characterization and antibacterial activities of bio-based schiff base Copper Complex intercalated montmorillonite

IF 5.3 2区地球科学 Q2 CHEMISTRY, PHYSICAL

Applied Clay Science Pub Date : 2025-04-04 DOI:10.1016/j.clay.2025.107809

Xianchang Liang , Wenjing Wang , Mingyuan Tang , Yuanyuan Kang , Mingjun Cui , Haichao Zhao

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引用次数: 0

Abstract

The direct use of antimicrobial agents has problems such as high effective dose and short antimicrobial duration. Therefore, encapsulation of antimicrobial agents in nanocontainers can improve stability and antimicrobial efficiency, reduce the risk of drug resistance, and lower the environmental impact. In this study, biomass-based Schiff base ligand (LAE-oVan) was synthesized by condensation of ethyl lauroyl arginate HCl and ortho-vanillin. Bio-based Schiff base copper complex intercalated montmorillonite was then prepared by pretreated montmorillonite (MMT) with Cu²⁺ exchange, followed by chelation with LAE-oVan to form antimicrobial nanocomposites (LAE-oVan-Cu@MMT). Release behavior studies have shown that LAE-oVan-Cu@MMT has a release time of up to 2250 min, and the releasable amount of Cu²⁺ and LAE-oVan was calculated to be about 35 %. Antibacterial activity was studied by zone of inhibition method, minimum inhibitory concentration method, plate colony counting method and biofilm method. The results showed that LAE-oVan-Cu@MMT achieved 99.99 % antibacterial ratio against Escherichia coli (E. coli) at 25 μg/mL within 1.5 h and Staphylococcus aureus (S. aureus) at 25 μg/mL within 3 h. Biofilms gradually decreased with increasing concentrations of LAE-oVan-Cu@MMT. Moreover, cytotoxicity studies showed that LAE-oVan-Cu@MMT had a low toxicity to L929 cells. This study provides a strategy for the development of novel antimicrobial with low toxic, eco-friendly and long term release efficiency.

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来源期刊

Applied Clay Science 地学-矿物学

CiteScore

10.30

自引率

10.70%

发文量

289

审稿时长

39 days

期刊介绍： Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...