Functional foods and nutraceuticals with anti-aging effects: Focus on modifying the enteral microbiome

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2025-04-04 DOI:10.1016/j.jff.2025.106786

Yingbi Xu , Jiao Song , Qi Huang , Xiaorong Wei , Zhiyan Deng , Zhenguang Song , Haozhou Huang , Chuanhong Luo , Dingkun Zhang , Li Han

{"title":"Functional foods and nutraceuticals with anti-aging effects: Focus on modifying the enteral microbiome","authors":"Yingbi Xu , Jiao Song , Qi Huang , Xiaorong Wei , Zhiyan Deng , Zhenguang Song , Haozhou Huang , Chuanhong Luo , Dingkun Zhang , Li Han","doi":"10.1016/j.jff.2025.106786","DOIUrl":null,"url":null,"abstract":"<div><div>Dietary intervention is an effective strategy for anti-aging, and functional foods have become an important choice because of their efficiency and convenience. By regulating Bacteroides, Prevotella, Lactobacillus, <em>Clostridium butyricum</em>, and other key flora, they alleviate muscle aging, immune aging, and metabolic disorders, thereby delaying the aging of the body. Studies have shown that functional foods such as polysaccharides, oligosaccharides, probiotics, dietary fiber, and dietary polyphenols have significant anti-aging effects. However, probiotics are easily inactivated by the internal environment in the gut, which affects their efficacy. Therefore, how to achieve efficient colonization of probiotics is the key of current research. Probiotic colonization plays an important role in protecting host health by maintaining intestinal microecological balance, enhancing barrier function, regulating the immune system, and promoting nutrient absorption. Through biofilm protection, structural optimization, or a combination with other functional foods, the stability of probiotics can be enhanced so that they can play a long-term role in the gut of aging populations. This review summarizes the characteristics and regulatory mechanisms of gut microbiome in the aging population, focuses on functional foods with anti-aging effects, and puts forward suggestions for the feasibility of efficient colonization of probiotics so as to provide a theoretical basis for the development of anti-aging foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106786"},"PeriodicalIF":3.8000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464625001288","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Dietary intervention is an effective strategy for anti-aging, and functional foods have become an important choice because of their efficiency and convenience. By regulating Bacteroides, Prevotella, Lactobacillus, Clostridium butyricum, and other key flora, they alleviate muscle aging, immune aging, and metabolic disorders, thereby delaying the aging of the body. Studies have shown that functional foods such as polysaccharides, oligosaccharides, probiotics, dietary fiber, and dietary polyphenols have significant anti-aging effects. However, probiotics are easily inactivated by the internal environment in the gut, which affects their efficacy. Therefore, how to achieve efficient colonization of probiotics is the key of current research. Probiotic colonization plays an important role in protecting host health by maintaining intestinal microecological balance, enhancing barrier function, regulating the immune system, and promoting nutrient absorption. Through biofilm protection, structural optimization, or a combination with other functional foods, the stability of probiotics can be enhanced so that they can play a long-term role in the gut of aging populations. This review summarizes the characteristics and regulatory mechanisms of gut microbiome in the aging population, focuses on functional foods with anti-aging effects, and puts forward suggestions for the feasibility of efficient colonization of probiotics so as to provide a theoretical basis for the development of anti-aging foods.

Abstract Image

查看原文本刊更多论文

具有抗衰老作用的功能食品和营养保健品：重点是改变肠道微生物群

饮食干预是抗衰老的有效策略，功能食品因其高效、方便而成为重要的选择。通过调节拟杆菌、普雷沃氏菌、乳酸杆菌、丁酸梭菌等关键菌群，缓解肌肉老化、免疫老化、代谢紊乱，从而延缓机体衰老。研究表明，多糖、低聚糖、益生菌、膳食纤维、膳食多酚等功能性食品具有显著的抗衰老作用。然而，益生菌很容易被肠道内环境灭活，从而影响其功效。因此，如何实现益生菌的高效定植是当前研究的重点。益生菌定殖在维持肠道微生态平衡、增强屏障功能、调节免疫系统、促进营养吸收等方面具有保护宿主健康的重要作用。通过生物膜保护、结构优化或与其他功能食品结合，可以增强益生菌的稳定性，使其在老年人肠道中长期发挥作用。本文综述了老年人群肠道菌群的特征及调控机制，重点研究了具有抗衰老作用的功能性食品，并对益生菌高效定植的可行性提出了建议，为抗衰老食品的开发提供理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.