Reversing Morphine Induced Tolerance: Insights Into Cetirizine and Green Tea Extract Efficacy

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Therapeutic Research-clinical and Experimental Pub Date : 2025-01-01 DOI:10.1016/j.curtheres.2025.100783

Tahereh Eteraf-Oskouei Phd , Adel Mahmoudi Gharehbaba Phd , Solmaz Asnaashari Phd , Zahra Fazli Phd , Bohloul Habibi Asl Phd

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引用次数: 0

Abstract

Background

The treatment of chronic pain presents a considerable difficulty, particularly due to opioid dependence, which is marked by tolerance and withdrawal symptoms. Opioids primarily target mu (μ) opioid receptors, providing pain relief while also leading to various side effects. This research aimed to examine the effectiveness of cetirizine and green tea hydroalcoholic extract (EXT) in altering morphine tolerance and improving analgesic effects.

Methods

Adult male mice were divided into nine groups. In order to investigate the analgesic tolerance, animals received morphine on 14 consecutive days. Cetirizine (5, 10, 20 mg/kg, i.p.) and EXT (50, 100, 200 mg/kg, i.p.) were given before a test dose of morphine (9 mg/kg, i.p.). The analgesic effects were evaluated by the hot plate test.

Results

Cetirizine with doses of 5, 10, 20 mg/kg, and 10 mg/kg showed a significant effect in reducing morphine tolerance 30 min (P < 0.0001) and 45 to 60 min (P < 0.0001) after test dose of morphine (9 mg/kg, i.p.) respectively. While the injection of different doses of the extract did not show any effect on tolerance to morphine. In the combined injection of these two drugs, there was no reduction in tolerance to morphine.

Conclusions

Cetirizine but not EXT reversed morphine tolerance. Furthermore, the co-administration of cetirizine and EXT did not yield any significant benefits compared to the individual treatments.

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逆转吗啡诱导的耐受性：西替利嗪和绿茶提取物疗效的见解

慢性疼痛的治疗呈现出相当大的困难，特别是由于阿片类药物依赖，其特征是耐受性和戒断症状。阿片主要靶向mu （μ）阿片受体，在缓解疼痛的同时也会导致各种副作用。本研究旨在探讨西替利嗪和绿茶水酒精提取物（EXT）改变吗啡耐受性和改善镇痛效果的有效性。方法将成年雄性小鼠分为9组。为了观察小鼠的镇痛耐受性，连续14天给予吗啡。在吗啡试验剂量（9 mg/kg, i.p）之前给予西替利嗪（5、10、20 mg/kg, i.p）和EXT（50、100、200 mg/kg, i.p）。采用热板法评价镇痛效果。结果西替利嗪剂量为5、10、20 mg/kg和10 mg/kg时，分别在吗啡试验剂量（9 mg/kg, i.p）后30 min （P <； 0.0001）和45 ~ 60 min （P <； 0.0001）显著降低吗啡耐受性。而注射不同剂量的提取物对吗啡耐受性没有任何影响。在联合注射这两种药物时，对吗啡的耐受性没有降低。结论西替利嗪对吗啡耐受有逆转作用，EXT对吗啡耐受无逆转作用。此外，与单独治疗相比，西替利嗪和EXT联合使用没有产生任何显著的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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