Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury

IF 8.7 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Jiangpeng Pan , Juntao Wang , Wei Wang , Ziyang Liu , Shuai Huo , Lei Yan , Wei Jiang , Fengmin Shao , Yue Gu
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引用次数: 0

Abstract

Mitochondrial dysfunction-induced oxidative stress is a key pathogenic factor in acute kidney injury (AKI). Despite this, current mitochondrial-targeted antioxidant therapies have shown limited efficacy in clinical settings. In this study, we introduce a novel renal-clearable and mitochondria-targeted antioxidant nanozyme (TPP@RuCDzyme) designed to precisely modulate mitochondrial oxidative stress and mitigate AKI progression. TPP@RuCDzyme was synthesized by integrating ruthenium-doped carbon dots (CDs) with triphenylphosphine (TPP), a mitochondria-targeting moiety. This nanozyme system exhibits cascade enzyme-like activities, mimicking superoxide dismutase (SOD) and catalase (CAT), to efficiently convert cytotoxic superoxide (O2-) and hydrogen peroxide (H2O2) into non-toxic water (H2O) and oxygen (O2). This dual-enzyme mimicry effectively alleviates mitochondrial oxidative damage, restores mitochondrial function, and inhibits apoptosis. Compared to RuCDzyme alone, TPP@RuCDzyme demonstrated significantly enhanced efficacy in alleviating glycerol-induced AKI by inhibiting oxidative stress. By leveraging the catalytic activity derived from the integration of CDs and a metallic element, this study presents a promising therapeutic strategy for AKI and other renal diseases associated with mitochondrial dysfunction.

Abstract Image

肾清除和线粒体靶向金属工程碳点纳米酶调节急性肾损伤线粒体氧化应激
线粒体功能障碍诱导的氧化应激是急性肾损伤(AKI)的重要致病因素。尽管如此,目前的线粒体靶向抗氧化疗法在临床环境中显示出有限的疗效。在这项研究中,我们引入了一种新的肾脏清除和线粒体靶向抗氧化纳米酶(TPP@RuCDzyme),旨在精确调节线粒体氧化应激和减缓AKI的进展。TPP@RuCDzyme是通过将钌掺杂碳点(CDs)与线粒体靶向片段三苯基膦(TPP)整合而成的。这种纳米酶系统具有级联酶样活性,模仿超氧化物歧化酶(SOD)和过氧化氢酶(CAT),有效地将细胞毒性超氧化物(O2•-)和过氧化氢(H2O2)转化为无毒的水(H2O)和氧(O2)。这种双酶模拟能有效减轻线粒体氧化损伤,恢复线粒体功能,抑制细胞凋亡。与单独使用RuCDzyme相比,TPP@RuCDzyme通过抑制氧化应激来缓解甘油诱导的AKI的疗效显著增强。通过利用CDs和金属元素整合产生的催化活性,本研究提出了一种有希望的治疗AKI和其他与线粒体功能障碍相关的肾脏疾病的策略。
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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