Total synthesis of conjugation ready repeating unit of Acinetobacter baumannii strain K141 capsular polysaccharide via a [2 + 2] convergent approach

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2025-04-01 DOI:10.1016/j.carres.2025.109478

Sunil K. Yadav, Somnath Yadav

引用次数: 0

Abstract

Acinetobacter baumannii is a well-known opportunistic gram-negative bacterium responsible for serious concerns to human health due to its high virulence and extensive resistance to numerous antibiotics such as carbapenem, colistin, tigecycline, and many more. Herein, we have conducted the first total synthesis of the repeating unit of Acinetobacter baumannii strain K141 via the convergent [2 + 2] approach featuring the coupling of β-L-Rhap-(1 → 4)-β-D-GlcpNAc and β-D-Galp-(1 → 3)-β-D-GlcpNAc units. The synthesis of the first disaccharide unit involved a stereoselective cis-rhamnosylation that was achieved via the picoloyl-induced hydrogen bond mediated aglycon delivery with high β-stereo control.

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".