Electrochemical sensor based on cobalt oxide-modified screen-printed carbon electrodes for hydrochlorothiazide detection in pharmaceutical formulation

IF 4.3 3区材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS

Diamond and Related Materials Pub Date : 2025-03-31 DOI:10.1016/j.diamond.2025.112263

Chenxi Wu , Mohammad Jahidul Alam , Shengzhou Qiu , Sima Akter , Shaoli Hong , Kazi N. Islam , Huihong Liu , Sakil Mahmud

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Abstract

Hydrochlorothiazide (HCT), a widely used thiazide diuretic, faces detection challenges due to low sensitivity, interference, and complex analysis methods. This study explores an innovative electrochemical sensor based on cobalt oxide-modified screen-printed carbon electrodes (CoO/SPCE) to enhance HCT detection. CoO was electrodeposited onto SPCE, optimizing parameters like the CoO concentration and electrodeposition time through cyclic voltammetry. Microscopic analysis confirmed smoother CoO/SPCE surfaces, indicative of improved structural integrity. The modified electrode demonstrated an oxidation peak at 0.242 V with a current of 5.8 μA for HCT, outperforming unmodified electrodes. Electrochemical impedance spectroscopy revealed a 495-fold decrease in charge transfer resistance after modification, underscoring enhanced electron transfer. The sensor exhibited a low limit of detection, minimal relative standard deviation for signal stability (RSD = 3.38 %), and consistent multi-electrode performance (RSD = 3.32 %). The linear relationship between peak current and HCT concentration, I = 0.01941c + 0.4319 (R² = 0.996), confirms the reliability of the method. This CoO/SPCE sensor offers simplicity and rapid detection, marking a significant advancement for in-field HCT analysis.

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基于氧化钴修饰网印碳电极的电化学传感器用于药物配方中氢氯噻嗪的检测

氢氯噻嗪（HCT）是一种广泛应用的噻嗪类利尿剂，由于其灵敏度低、干扰大、分析方法复杂等问题，在检测中面临着挑战。本研究探索了一种基于氧化钴修饰的丝网印刷碳电极（CoO/SPCE）的新型电化学传感器，以增强HCT检测。将CoO电沉积到SPCE上，通过循环伏安法优化CoO浓度和电沉积时间等参数。显微分析证实CoO/SPCE表面更光滑，表明结构完整性得到改善。修饰电极在0.242 V处出现氧化峰，HCT电流为5.8 μA，优于未修饰电极。电化学阻抗谱显示，改性后的电荷转移电阻降低了495倍，表明电子转移增强。该传感器具有较低的检测限、最小的信号稳定性相对标准偏差（RSD = 3.38%）和一致的多电极性能（RSD = 3.32%）。峰值电流与HCT浓度呈线性关系，I = 0.01941c + 0.4319 (R2 = 0.996)，验证了方法的可靠性。这种CoO/SPCE传感器提供简单和快速的检测，标志着现场HCT分析的重大进步。

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来源期刊

Diamond and Related Materials 工程技术-材料科学：综合

CiteScore

6.00

自引率

14.60%

发文量

702

审稿时长

2.1 months

期刊介绍： DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices. The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.