Inter-organ communication in Drosophila: Lipoproteins, adipokines, and immune-metabolic coordination

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-04-04 DOI:10.1016/j.ceb.2025.102508

Akhila Rajan , Jason Karpac

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Abstract

Inter-organ communication networks are essential for maintaining systemic homeostasis in multicellular organisms. In Drosophila melanogaster, studies of adipokines and lipoproteins reveal evolutionarily conserved mechanisms coordinating metabolism, immunity, and behavior. This mini-review focuses on two key pathways: the adipokine Unpaired 2 (Upd2) and lipoprotein-mediated signaling. Upd2, a leptin analog, mediates fat-brain communication to regulate insulin secretion, sleep, and feeding behavior. Recent work has uncovered an LC3/Atg8-dependent secretion mechanism for Upd2, linking nutrient sensing to systemic adaptation. Lipoproteins, particularly ApoLpp and LTP, function beyond lipid transport, orchestrating neural maintenance and immune responses. During infection, macrophage-derived signals trigger lipoprotein-mediated lipid redistribution to support host defense. Additionally, muscle tissue emerges as an unexpected mediator of immune-metabolic coordination through inter-organ signaling. These findings highlight the intricate cross-talk between organs required for organismal survival and suggest therapeutic strategies for metabolic disorders.

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果蝇的器官间通讯：脂蛋白、脂肪因子和免疫代谢协调

在多细胞生物中，器官间通讯网络对于维持系统稳态至关重要。在黑腹果蝇中，对脂肪因子和脂蛋白的研究揭示了协调代谢、免疫和行为的进化保守机制。这篇综述主要关注两个关键途径：脂肪因子Unpaired 2 （Upd2）和脂蛋白介导的信号传导。Upd2是一种瘦素类似物，介导脂肪与大脑的交流，调节胰岛素分泌、睡眠和摄食行为。最近的研究揭示了Upd2的LC3/ atg8依赖性分泌机制，将营养感知与系统适应联系起来。脂蛋白，尤其是ApoLpp和LTP，除了脂质转运之外，还具有协调神经维持和免疫反应的功能。在感染过程中，巨噬细胞来源的信号触发脂蛋白介导的脂质再分配来支持宿主防御。此外，肌肉组织通过器官间信号传导成为免疫代谢协调的意想不到的中介。这些发现强调了生物体生存所需的器官之间复杂的串扰，并提出了代谢紊乱的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.