Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS)

IF 2.1 Q3 CRITICAL CARE MEDICINE

Resuscitation plus Pub Date : 2025-03-20 DOI:10.1016/j.resplu.2025.100938

Pin Pin Pek , Megan Chua , Le Xuan Liew , Christina Chen , Shir-Lynn Lim , Felix Maverick Rubillar Uy , Vui Kian Ho , Yew Woon Chia , Jia Min Chua , Ee Ling Goh , Lai Peng Tham , Pei Lin Koh , Kai Lee Woo , Cheryl Ting Zhen Woo , Iylia Muhammad Afiq , Kexin Fang , Han Nee Gan , Benjamin Sieu-Hon Leong , Desmond Ren-Hao Mao , Nausheen Edwin Doctor , Andrew Fu Wah Ho

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Abstract

Background

Out-of-hospital cardiac arrest (OHCA) is an emergency with historically low survival rates. Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. However, there is insufficient high-quality population-based long-term survivorship data and limited research on the impact of OHCA sequelae on survivors’ caregivers.

Objective

Our primary aim is to determine neurological function, physical, psychological, cognitive, social outcomes, and health-related quality of life (HRQoL) of OHCA survivors in Singapore. Secondary aims are to quantify caregivers’ burden and its association with their HRQoL, and psychological well-being.

Methods

The Quality Cardiac Arrest Survivorship Cohort Study (QualiCAS) is a prospective population-based cohort study of OHCA survivors and their caregivers in Singapore. Participants aged ≥18 years and caregivers aged ≥21 years will be recruited from all public hospitals in Singapore. Health outcomes will be evaluated at 3, 6, and 12 months, and 3 and 5 years using the Hospital Anxiety and Depression Scale, PTSD Checklist for DSM-5, Fatigue Severity Scale, Montreal Cognitive Assessment Tool, EQ-5D-5L, Community Integration Questionnaire-Revised, Barthel Index, Lawton’s Instrumental Activities of Daily Living, Timed Up and Go Test, Handgrip strength assessment, and Zarit Burden Interview.

Discussion

This study allows us to understand the natural history of OHCA survivorship and quantify the burdens on patients and their caregivers. Findings can guide clinical follow-up, identify high-risk patients, intervention targets, and inform rehabilitation strategies for OHCA sequelae.

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院外心脏骤停幸存者及其照护者的身体、心理、认知、社会健康结局和健康相关生活质量：高质量心脏骤停幸存者队列研究（QualiCAS）方案

院外心脏骤停（OHCA）是一种历史上生存率较低的急诊。复苏和复苏后护理的进步提高了生存率，促使人们对OHCA患者的生存率产生了更大的科学兴趣。然而，缺乏高质量的基于人群的长期生存数据，并且关于OHCA后遗症对幸存者照顾者影响的研究有限。我们的主要目的是确定新加坡OHCA幸存者的神经功能、身体、心理、认知、社会结果和健康相关生活质量（HRQoL）。次要目的是量化照顾者的负担及其与他们的HRQoL和心理健康的关系。方法高质量心脏骤停幸存者队列研究（QualiCAS）是一项基于新加坡OHCA幸存者及其护理人员的前瞻性人群队列研究。年龄≥18岁的受试者和年龄≥21岁的护理人员将从新加坡所有公立医院招募。采用医院焦虑抑郁量表、DSM-5 PTSD检查表、疲劳严重程度量表、蒙特利尔认知评估工具、EQ-5D-5L、修订社区融入问卷、Barthel指数、劳顿日常生活工具活动、Timed Up and Go测试、握力评估和Zarit Burden访谈对3、6、12个月和3、5年的健康结果进行评估。本研究使我们能够了解OHCA生存的自然历史，并量化患者及其护理人员的负担。研究结果可以指导临床随访，识别高危患者，确定干预目标，并为OHCA后遗症的康复策略提供指导。

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