Self-Assembled Gd/Cyanine Nanoplatform for Magnetic Resonance Imaging Guided Photothermal Therapy of Thyroid Cancer

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2025-03-25 DOI:10.1021/acsanm.5c0040910.1021/acsanm.5c00409

Changzhi Guo, Fulin Li, Shuang Wu, Chunxiang Li, Tingxing Hou, Guohua Li, Jing Guo, Xiaoxin Wang, Liguo Hao* and Zhongyuan Li*,

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引用次数: 0

Abstract

Thyroid cancer, a prevalent endocrine malignancy with rising incidence, necessitates advanced strategies for precise diagnosis and effective treatment. In this study, we develop a self-assembled gadolinium-cyanine coordination-driven nanoscale metal–organic particle (CyO/Gd NPs) that seamlessly integrates magnetic resonance imaging (MRI) and photothermal therapy (PTT) for enhanced theranostic applications. The coordination-driven self-assembly endows CyO/Gd NPs with superior photostability and significantly enhanced photothermal conversion efficiency (∼50.3%) under near-infrared laser irradiation, surpassing free cyanine dyes. These nanoparticles effectively induce apoptosis and necrosis in thyroid cancer cells and exhibit potent in vivo antitumor efficacy. Furthermore, the incorporated Gd³⁺ ions act as T₁-weighted MRI contrast agents, facilitating precise tumor localization and real-time monitoring of therapeutic progress. By bridging imaging and therapy, CyO/Gd NPs offer a robust multifunctional platform for thyroid cancer theranostics, paving the way for next-generation integrated diagnostic and therapeutic nanoplatforms.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.