Effects of One-Month Very-Low-Calorie Ketogenic Diet on 24 h Energy Metabolism and Body Composition in Women with Obesity.

IF 5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-04-02 DOI:10.1210/clinem/dgaf196

Alessio Basolo, Paolo Piaggi, Valentina Angeli, Paola Fierabracci, Chiara Bologna, Edda Vignali, Daniela Troiani, Roberta Jaccheri, Caterina Pelosini, Melania Paoli, Guido Salvetti, Luca Chiovato, Jonathan Krakoff, Alberto Landi, Ferruccio Santini

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引用次数: 0

Abstract

Context: Very-low-calorie ketogenic diet (VLCKD) is used for weight loss and management of obesity-related comorbidities.

Objective: We aimed at evaluating the effects of VLCKD on body composition and energy metabolism.

Methods: This prospective outpatient study included 17 women with obesity (mean age 41.6 yrs; BMI 37.5 kg/m2) who followed a 1-month VLCKD (700-800 kcal/day, CHO 11%, fat 46%, protein 43%) at the University Hospital of Pisa. Measurements of 24-hour energy expenditure (24hEE) and substrate oxidation were conducted in a metabolic chamber at day 1 (V1), day 8 (V2), and day 29 (V3). Body composition was assessed by DXA. Twenty-two women with obesity fed a balanced isocaloric diet served as controls.

Results: Compared to controls, carbohydrate oxidation (CarbOx) was lower, whereas fat oxidation (FatOx) and protein oxidation (ProtOx) were higher in the VLCKD group at V1. CarbOx decreased by 65%, while FatOx increased by 11% at V3. The rate of protein oxidation was already higher than in controls at V1 and remained stable throughout the study. After 1 month, body weight decreased by 7%, reflecting an 8.8% reduction in fat mass (FM) and a 5.6% reduction in lean soft tissue (LST). A 10% decrease in 24hEE and 24 h sleeping metabolic rate was observed at V3 compared to V1.

Conclusion: VLCKD promotes weight loss in women with obesity. Our findings highlight the shift in energy metabolism towards increased fat oxidation accompanied by a modest increase in protein oxidation, a decrease in LST and a reduction in EE.

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来源期刊

Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

11.40

自引率

5.20%

发文量

673

审稿时长

1 months

期刊介绍： The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.