Prognostic value of TNF-α, PCT, IL-8, and HBP, combined with APACHE II score in patients with sepsis.

IF 1.4 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI:10.3855/jidc.20383

Shuping Guo, Chunyan Liao, Qinghong Liu

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引用次数: 0

Abstract

Introduction: This study evaluated the prognostic value of serum cytokines tumor necrosis factor-alpha (TNF-α), procalcitonin (PCT), interleukin-8 (IL-8), and heparin binding protein (HBP); combined with acute physiology and chronic health evaluation II (APACHE II) score in sepsis patients.

Methodology: Patients were divided into sepsis and septic shock groups based on sepsis-3 criteria, with non-sepsis individuals as controls. Serum TNF-α, PCT, IL-8, and HBP levels; and APACHE II scores were recorded upon intensive care unit (ICU) admission. The diagnostic value was evaluated using receiver operating characteristic (ROC) curves and areas under the curves (AUCs).

Results: Correlation analysis revealed that serum TNF-α (r = 0.701), PCT (r = 0.623), IL-8 (r = 0.617), and HBP (r = 0.721) were positively correlated with the APACHE II score (p < 0.05). Serum TNF-α, PCT, IL-8, HBP levels, and APACHE II scores were significantly higher in non-survivors than survivors (p < 0.05). The AUC for combined indicators in predicting mortality was 0.913 (confidence interval, CI: 0.861-0.912), significantly higher than individual indicators. HBP showed AUC of 0.798 (CI: 0.707-0.879) and APACHE II 0.769 (CI: 0.782-0.892). The combined prediction demonstrated 96.21% sensitivity and 79.34% specificity.

Conclusions: Serum TNF-α, PCT, IL-8, and HBP levels influenced sepsis patient prognosis, and their combined detection with APACHE II score provided a high predictive value for patient outcomes.

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脓毒症患者TNF-α、PCT、IL-8和HBP与APACHE II评分的预后价值。

导言本研究评估了脓毒症患者血清细胞因子肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）、白细胞介素-8（IL-8）和肝素结合蛋白（HBP）与急性生理学和慢性健康评价 II（APACHE II）评分相结合的预后价值：根据脓毒症-3标准将患者分为脓毒症组和脓毒性休克组，非脓毒症患者作为对照组。重症监护室（ICU）入院时记录血清 TNF-α、PCT、IL-8 和 HBP 水平以及 APACHE II 评分。使用接收者操作特征曲线（ROC）和曲线下面积（AUC）评估诊断价值：相关性分析显示，血清 TNF-α (r = 0.701)、PCT (r = 0.623)、IL-8 (r = 0.617) 和 HBP (r = 0.721) 与 APACHE II 评分呈正相关（P < 0.05）。非幸存者的血清 TNF-α、PCT、IL-8、HBP 水平和 APACHE II 评分均显著高于幸存者（P < 0.05）。综合指标预测死亡率的AUC为0.913（置信区间，CI：0.861-0.912），明显高于单个指标。HBP 的 AUC 为 0.798（置信区间：0.707-0.879），APACHE II 为 0.769（置信区间：0.782-0.892）。综合预测的灵敏度为 96.21%，特异度为 79.34%：血清TNF-α、PCT、IL-8和HBP水平影响脓毒症患者的预后，它们与APACHE II评分的联合检测对患者的预后具有很高的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.