Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-04-01 DOI:10.1167/tvst.14.4.3

Samantha Sze-Yee Lee, Gareth Lingham, Alex W Hewitt, David A Mackey

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引用次数: 0

Abstract

Purpose: Age-related changes in glaucoma endophenotypes have been described thoroughly, yet, there are limited data on the normal age-related changes in young adults. This study profiles the 8-year longitudinal change in peripapillary retinal nerve fiber layer (pRNFL), intraocular pressure (IOP), and central corneal thickness (CCT) in young adults.

Methods: A community-based cohort of young adults from the Raine Study underwent eye examinations that included optical coherence tomography of the optic disc, tonometry, and pachymetry when they were 20 and 28 years old. The main outcome measures were the changes in pRNFL thickness, IOP, and CCT over 8 years, adjusted for sex, ethnicity, and other potential confounders.

Results: A total of 693, 712, and 680 participants were included in the pRNFL, IOP, and CCT analyses, respectively. Over the 8 years, the global pRNFL reduced from a mean of 100.6 ± 9.3 to 97.9 ± 9.4 µm, at an average rate of 0.27 µm/year (95% confidence interval [CI], 0.24-0.30). Sectoral pRNFL similarly thinned by 0.06 to 0.38 µm/year, but this thinning was not statistically significant at the superotemporal and inferonasal sectors. IOP decreased and CCT increased between 20 and 28 years old, at an average rate of 0.18 mm Hg/year (95% CI, 0.15-0.20) and 0.18 µm/year (95% CI, 0.10-0.27), respectively.

Conclusions: During the third decade of life, there is a decrease in pRNFL thickness and IOP in healthy adults.

Translational relevance: The current study findings will enable clinicians to differentiate potential pathological change from normal age-related variations in these measures.

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青壮年视网膜神经纤维层厚度和眼压的纵向变化。

目的：青光眼内部表型的年龄相关变化已经被详细描述，然而，关于青光眼正常年龄相关变化的数据有限。本研究描述了年轻人乳头周围视网膜神经纤维层（pRNFL）、眼压（IOP）和角膜中央厚度（CCT） 8年的纵向变化。方法：来自Raine研究的以社区为基础的年轻人队列在他们20岁和28岁时接受了眼科检查，包括视盘光学相干断层扫描、眼压测量和视厚测量。主要结局指标为8年来pRNFL厚度、IOP和CCT的变化，并根据性别、种族和其他潜在混杂因素进行了调整。结果：pRNFL、IOP和CCT分析分别纳入了693、712和680名参与者。在8年中，全球pRNFL从平均100.6±9.3µm减少到97.9±9.4µm，平均速率为0.27µm/年（95%置信区间[CI]， 0.24-0.30）。部门pRNFL同样变薄0.06至0.38µm/年，但这种变薄在颞上和鼻间部门没有统计学意义。在20 - 28岁之间，IOP下降，CCT增加，平均速率分别为0.18 mm Hg/年（95% CI, 0.15-0.20）和0.18µm/年（95% CI, 0.10-0.27）。结论：在生命的第三个十年，健康成人的pRNFL厚度和IOP下降。翻译相关性：目前的研究结果将使临床医生能够区分这些指标中潜在的病理改变和正常的年龄相关变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.