Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-04-01 DOI:10.1167/tvst.14.4.2

Hui Liu, Suo Guo, Yaning Liu, Guannan Su, Peizeng Yang

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引用次数: 0

Abstract

Purpose: To identify the subtypes among patients clinically diagnosed as herpetic anterior uveitis (HAU) and characterize their clinical features and visual prognosis.

Methods: Three hundred and seventeen patients were clinically diagnosed as HAU in our department. Aqueous humor (AqH) and serum were collected from 43 of 317 HAU patients during eye surgery. Pathogens were identified using droplet digital polymerase chain reaction and the Goldmann-Witmer coefficient. The AqH levels of 10 inflammatory cytokines were measured. The demographics, clinical features, treatment, and visual prognosis of the subtypes of HAU identified by AqH analysis were analysed.

Results: DNA for herpes simplex virus (HSV), varicella-zoster virus (VZV), and cytomegalovirus (CMV) were identified in 13,18 and 12 eyes, respectively. The AqH levels of interleukin-13, interferon-γ, and tumor necrosis factor-α were significantly higher in VZV-AU as compared with HSV-AU and CMV-AU (all P < 0.05). In general, all these three subtypes of HAU had clinical features in common, including mutton-fat keratic precipitates usually toned with pigmentation, iris atrophy, elevated intraocular pressure (IOP), and posterior synechia with pupil pulling appearance unlike that caused by other uveitis. A much higher IOP and poor visual acuity at first visit were more commonly observed in VZV-AU and CMV-AU as compared with HSV-AU (both P < 0.05). A poor visual prognosis was noted in VZV-AU as compared with HSV-AU and CMV-AU (P = 0.010).

Conclusions: Our study identified three subtypes of HAU and characterized their clinical features. VZV-AU is frequently associated with much higher IOP and a poor visual prognosis.

Translational relevance: We addressed the similarity and difference regarding clinical features and visual prognosis among three subtypes of HAU and also found droplet digital polymerase chain reaction is a sensitive technique for identifying its subtypes throughout the disease course.

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中国人群疱疹性前葡萄膜炎亚型的鉴定及其临床特征和视力结果的表征。

目的：鉴定临床诊断为疱疹性葡萄膜前炎（HAU）患者的亚型，探讨其临床特征和视力预后。方法：我院临床诊断为HAU的患者317例。317例HAU患者中有43例在眼科手术中采集房水（AqH）和血清。采用液滴数字聚合酶链反应和Goldmann-Witmer系数对病原菌进行鉴定。测定10种炎性细胞因子的AqH水平。分析AqH分析确定的HAU亚型的人口学特征、临床特征、治疗和视觉预后。结果：单纯疱疹病毒（HSV）、水痘带状疱疹病毒（VZV）和巨细胞病毒（CMV）分别在13只、18只和12只眼睛中检测到DNA。VZV-AU中白细胞介素-13、干扰素-γ和肿瘤坏死因子-α的AqH水平显著高于HSV-AU和CMV-AU（均P < 0.05）。总的来说，这三种HAU亚型具有共同的临床特征，包括羊脂肪角化沉淀，通常伴有色素沉着，虹膜萎缩，眼压升高，与其他葡萄膜炎不同的是，后粘连伴瞳孔拉直。VZV-AU和CMV-AU患者与HSV-AU患者相比，首次就诊时眼压明显升高，视力较差（P均< 0.05）。与HSV-AU和CMV-AU相比，VZV-AU的视力预后较差（P = 0.010）。结论：我们的研究确定了三种HAU亚型，并描述了它们的临床特征。VZV-AU常伴有较高的IOP和较差的视力预后。翻译相关性：我们分析了三种HAU亚型在临床特征和视觉预后方面的异同，并发现液滴数字聚合酶链反应是一种在整个病程中识别其亚型的敏感技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.