Triglyceride-glucose index and lipid ratios in women with and without polycystic ovary syndrome: a systematic review and meta-analysis.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Therapeutic Advances in Endocrinology and Metabolism Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI:10.1177/20420188251328840

Juan R Ulloque-Badaracco, Esteban A Alarcon-Braga, Enrique A Hernandez-Bustamante, Juan C Cabrera-Guzmán, Giuseppe Dotto-Vasquez, Gian F Maldonado-Basurto, Germán Rivera-Cabrera, Sherelym H Maita-Arauco, Andres A Horruitiner-Mendoza, Percy Herrera-Añazco, Vicente A Benites-Zapata, Faustino R Pérez-López

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Abstract

Background: The pathophysiology of polycystic ovary syndrome (PCOS) is complex and heterogeneous. This systematic review and meta-analysis aimed to determine the triglyceride-glucose index and lipid ratios in women with and without PCOS.

Methods: Literature searches were performed in PubMed, Scopus, Web of Science, Scielo, and Embase for studies reporting the triglyceride-glucose index and total cholesterol/high-density lipoprotein (HDL)-cholesterol, triglyceride/HDL-cholesterol, and low-density lipoprotein (LDL)-cholesterol/HDL-cholesterol ratios. Results are reported as standardized mean differences (SMDs) along with their 95% confidence intervals (CIs).

Results: The search identified 61 observational studies, including case-control (n = 37), cohort (n = 2), and cross-sectional (n = 22) studies reporting results of interest according to different PCOS diagnosis criteria. Compared with the control group, the PCOS group presented increased circulating triglyceride-glucose index (n = 9 studies, SMD, 0.41; 95% CI, 0.08-0.74) and total cholesterol/HDL-cholesterol (n = 35 studies, SMD, 1.70; 95% CI, 0.69-2.70), triglyceride/HDL-cholesterol (n = 31 studies; SMD, 0.81; 95% CI, 0.43-1.19), and LDL-cholesterol/HDL-cholesterol (n = 25 studies, SMD, 2.40; 95% CI, 0.45-4.35) ratios. Statistical heterogeneity values were very high (I ² > 90%). The PCOS group displayed significantly higher body mass index and homeostatic model assessment of insulin resistance. The PCOS group was younger than the control group and had a higher total cholesterol/HDL-cholesterol ratio, and other lipid variables were comparable in all groups.

Conclusion: Patients with PCOS show significantly higher triglyceride-glucose index and total cholesterol/HDL-cholesterol, triglyceride/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol ratios than those without the syndrome.

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有和无多囊卵巢综合征妇女的甘油三酯-葡萄糖指数和脂质比率：一项系统回顾和荟萃分析。

背景：多囊卵巢综合征（PCOS）的病理生理是复杂和异质性的。本系统综述和荟萃分析旨在确定患有和未患有多囊卵巢综合征的妇女的甘油三酯-葡萄糖指数和脂质比率。方法：在PubMed、Scopus、Web of Science、Scielo和Embase中进行文献检索，检索有关甘油三酯-葡萄糖指数、总胆固醇/高密度脂蛋白(HDL)-胆固醇、甘油三酯/高密度脂蛋白-胆固醇和低密度脂蛋白(LDL)-胆固醇/高密度脂蛋白-胆固醇比率的研究。结果报告为标准化平均差异（SMDs）及其95%置信区间（ci）。结果：检索确定了61项观察性研究，包括病例对照（n = 37），队列（n = 2）和横断面（n = 22）研究，根据不同的PCOS诊断标准报告了感兴趣的结果。与对照组相比，PCOS组出现循环甘油三酯-葡萄糖指数升高(n = 9项研究，SMD, 0.41；95% CI, 0.08-0.74)和总胆固醇/高密度脂蛋白胆固醇(n = 35项研究，SMD, 1.70；95% CI, 0.69-2.70)，甘油三酯/高密度脂蛋白胆固醇(n = 31项研究；SMD, 0.81;95% CI, 0.43-1.19)， ldl -胆固醇/ hdl -胆固醇(n = 25项研究，SMD, 2.40；95% CI, 0.45-4.35)。统计异质性值非常高（2 ~ 90%）。多囊卵巢综合征组表现出更高的体重指数和胰岛素抵抗的稳态模型评估。PCOS组比对照组更年轻，总胆固醇/高密度脂蛋白胆固醇比值更高，各组其他脂质变量具有可比性。结论：PCOS患者甘油三酯-葡萄糖指数、总胆固醇/高密度脂蛋白胆固醇、甘油三酯/高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值明显高于无PCOS患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

7.70

自引率

2.60%

发文量

审稿时长

8 weeks

期刊介绍： Therapeutic Advances in Endocrinology and Metabolism delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of endocrinology and metabolism.