Thomas Beiter, Gunnar Erz, Anna Würden, Andreas M Nieß
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引用次数: 0
Abstract
In the present study, we aimed to determine the effect of moderate ambient heat stress on exercise-provoked patterns of "leaky gut" biomarkers and stress markers in well-trained athletes. Eleven triathletes performed a strenuous 1-h treadmill run, both under normal ambient conditions (N, 18-21°C) as well as under moderate heat environmental conditions (H, 28-30°C). Core body temperature (Tc), heart rate (HR), and rating of perceived exertion (RPE) significantly increased under both conditions, with significantly higher values during and after the H run. We observed a significant main effect of acute exercise on circulating leukocyte numbers, release of cell-free human DNA (cfDNA) but not bacterial DNA (bacDNA), and on plasma levels of intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide-binding protein (LBP), endotoxin (LPS), and D-lactate. Exercising under H conditions accelerated the mobilization of circulating neutrophils and lymphocytes, and significantly affected the release of cfDNA, D-lactate, I-FABP, creatinine, and blood potassium levels. Multiple correlation analysis revealed a significant association between Tc, max and exercise-provoked release of cfDNA (r = 0.583, p = 0.012) as well as with I-FABP (r = 0.554, p = 0.026). Our data indicate that acute exercising and heat stress may not only affect paracellular but also transcellular intestinal permeability.
期刊介绍:
Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.