Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes.

IF 2.2 Q3 PHYSIOLOGY
Thomas Beiter, Gunnar Erz, Anna Würden, Andreas M Nieß
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引用次数: 0

Abstract

In the present study, we aimed to determine the effect of moderate ambient heat stress on exercise-provoked patterns of "leaky gut" biomarkers and stress markers in well-trained athletes. Eleven triathletes performed a strenuous 1-h treadmill run, both under normal ambient conditions (N, 18-21°C) as well as under moderate heat environmental conditions (H, 28-30°C). Core body temperature (Tc), heart rate (HR), and rating of perceived exertion (RPE) significantly increased under both conditions, with significantly higher values during and after the H run. We observed a significant main effect of acute exercise on circulating leukocyte numbers, release of cell-free human DNA (cfDNA) but not bacterial DNA (bacDNA), and on plasma levels of intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide-binding protein (LBP), endotoxin (LPS), and D-lactate. Exercising under H conditions accelerated the mobilization of circulating neutrophils and lymphocytes, and significantly affected the release of cfDNA, D-lactate, I-FABP, creatinine, and blood potassium levels. Multiple correlation analysis revealed a significant association between Tc, max and exercise-provoked release of cfDNA (r = 0.583, p = 0.012) as well as with I-FABP (r = 0.554, p = 0.026). Our data indicate that acute exercising and heat stress may not only affect paracellular but also transcellular intestinal permeability.

跑步运动中适度环境热应激对耐力运动员胃肠完整性循环指标的影响。
在本研究中,我们旨在确定中度环境热应激对训练有素的运动员运动诱发的 "肠道渗漏 "生物标志物和应激标志物模式的影响。11 名铁人三项运动员在正常环境条件(N,18-21°C)和中度热环境条件(H,28-30°C)下进行了 1 小时的剧烈跑步。在这两种条件下,核心体温(Tc)、心率(HR)和体力消耗等级(RPE)都明显升高,其中在 H 跑期间和之后的数值明显更高。我们观察到,急性运动对循环白细胞数量、无细胞人类 DNA(cfDNA)释放(而非细菌 DNA(bacDNA))以及血浆中的肠道脂肪酸结合蛋白(I-FABP)、脂多糖结合蛋白(LBP)、内毒素(LPS)和 D-乳酸盐水平有明显的主效应。在 H 条件下运动会加速循环中性粒细胞和淋巴细胞的动员,并显著影响 cfDNA、D-乳酸盐、I-FABP、肌酐和血钾水平的释放。多重相关分析表明,Tc、max 与运动诱发的 cfDNA 释放量(r = 0.583,p = 0.012)以及 I-FABP 释放量(r = 0.554,p = 0.026)之间存在显著相关性。我们的数据表明,急性运动和热应激不仅会影响细胞旁通透性,还会影响跨细胞肠道通透性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physiological Reports
Physiological Reports PHYSIOLOGY-
CiteScore
4.20
自引率
4.00%
发文量
374
审稿时长
9 weeks
期刊介绍: Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.
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