Characterizing the Influence of Relative Humidity and Ethanol Content on the Dynamic Size Distributions of Aerosols Generated from a Soft Mist Inhaler.

IF 3.5 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Pharmaceutical Research Pub Date : 2025-04-01 DOI:10.1007/s11095-025-03851-1

Yiliang Lance Jiang, Jose R Ruiz, Richard Friend, Jonathan P Reid

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引用次数: 0

Abstract

Objective: Inhaled drug delivery systems need to ensure that the delivered aerosol effectively reach the lungs while overcoming challenges related to environmental conditions, such as relative humidity (RH). This study investigates the impact of environmental factors on aqueous aerosol behaviour using a Respimat® Soft Mist Inhaler (SMI) formulated with and without ethanol content.

Methods: Comparative Hygroscopic Aerosol Particle Sizing (CHAPS) was used to measure aerosol size distribution under varying RH levels, while single droplet analysis was conducted using Comparative Kinetics-Electrodynamic Balance (CK-EDB) to assess particle behaviour.

Results: The findings reveal that increased RH results in larger particle sizes, while elevated ethanol content consistently decreases both particle size and mass. The strong agreement between CHAPS measurements and CK-EDB data suggests that aerosol plume behaviour can be accurately modelled from single droplet data.

Conclusion: The study highlights ethanol's role in optimizing particle size distribution, which is crucial for enhancing the therapeutic efficiency of inhaled medications. These results underscore the importance of tailoring formulation and environmental conditions to improve drug delivery outcomes in pulmonary therapies and the importance of recognising that aerosol particle size distributions are dynamic and highly compositionally dependent.

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表征相对湿度和乙醇含量对软雾吸入器产生的气溶胶动态尺寸分布的影响。

目的：吸入式药物输送系统需要确保所输送的气溶胶有效到达肺部，同时克服与环境条件相关的挑战，如相对湿度（RH）。本研究使用含有和不含乙醇的Respimat®软雾吸入器（SMI）研究环境因素对水性气溶胶行为的影响。方法：采用比较吸湿气溶胶粒径法（CHAPS）测量不同相对湿度下气溶胶粒径分布，采用比较动力学-电平衡法（CK-EDB）对单个液滴进行分析，评估颗粒行为。结果：研究结果表明，增加的相对湿度导致更大的颗粒尺寸，而升高的乙醇含量始终降低颗粒尺寸和质量。CHAPS测量值与CK-EDB数据之间的强烈一致性表明，气溶胶羽流行为可以从单个液滴数据精确地模拟。结论：乙醇在优化颗粒粒径分布中的作用，对提高吸入性药物的治疗效果至关重要。这些结果强调了调整配方和环境条件以改善肺部治疗药物递送结果的重要性，以及认识到气溶胶粒径分布是动态的和高度依赖于成分的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.