Investigating the effects of rosmarinic acid on ovarian tissue, inflammatory markers, and sex hormones in polycystic ovary syndrome rats.

IF 2.2 Q3 PHYSIOLOGY

Physiological Reports Pub Date : 2025-04-01 DOI:10.14814/phy2.70304

Sina Vakili, Farhad Koohpeyma, Mohammad Samare-Najaf, Bahia Namavar Jahromi, Morteza Jafarinia, Sepide Goharitaban, Amir Savardashtaki, Ali Samareh, Fatemeh Amini, Mohammad Hashem Hashempur

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Abstract

Polycystic ovary syndrome (PCOS) causes the impairment of female fertility and elevates the risk of metabolic disorders. The current study aimed to evaluate the effects of rosmarinic acid (Ros) on the ovarian histo-stereology, the level of reproductive hormones, and inflammation in a rat model of PCOS. Fifteen adult Sprague Dawley rats were randomly divided into three groups, including controls, PCOS, and PCOS+Ros (receiving 25 mg/kg of Ros for 39 days). After treatments, the ovarian histo-stereology, the level of reproductive hormones, and the level of inflammatory markers were analyzed. PCOS led to increased ovarian weight and volume, cortical and medullary expansion, reduced ovarian follicles, and enhanced follicular atresia. It also caused hormonal imbalances, elevating LH, FSH, and testosterone while decreasing estradiol, progesterone, and AMH. Additionally, PCOS increased pro-inflammatory markers (TNF-α and IL-6) and decreased anti-inflammatory markers (IL-4 and IL-10). However, Ros administration in PCOS animals improved ovarian structure, increased follicle numbers, reduced atresia, balanced reproductive hormones, and restored inflammatory markers (p value <0.05). The present findings may suggest Ros as a novel strategy for the management of PCOS, although further studies are necessary.

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多囊卵巢综合征（PCOS）会导致女性生育能力受损，并增加代谢紊乱的风险。本研究旨在评估迷迭香酸（Ros）对多囊卵巢综合征大鼠模型的卵巢组织病理学、生殖激素水平和炎症的影响。15 只成年 Sprague Dawley 大鼠被随机分为三组，包括对照组、多囊卵巢综合征组和多囊卵巢综合征+Ros 组（连续 39 天服用 25 毫克/千克的迷迭香酸）。治疗后，对卵巢组织病理学、生殖激素水平和炎症标志物水平进行了分析。多囊卵巢综合征导致卵巢重量和体积增加、皮质和髓质扩张、卵泡减少和卵泡闭锁。多囊卵巢综合症还导致内分泌失调，使促性腺激素（LH）、前列腺素（FSH）和睾酮（Testosterone）升高，而雌二醇（Estradiol）、孕酮（Progesterone）和AMH则降低。此外，多囊卵巢综合症还会增加促炎标志物（TNF-α 和 IL-6），降低抗炎标志物（IL-4 和 IL-10）。然而，在多囊卵巢综合症动物体内施用 Ros 能改善卵巢结构，增加卵泡数量，减少闭锁，平衡生殖激素，并恢复炎症指标（p 值为 0.05）。

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.