Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy from Frontotemporal Dementia?

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-04-02 DOI:10.1002/mdc3.70058

Mauro César Quintão E Silva Cunningham, Sarah Teixeira Camargos, Vinícius Ribeiro Jeunon, Natalia Pessoa Rocha, Antônio Lúcio Teixeira, Thiago de Oliveira Maciel, Elisa de Paula França Resende, Francisco Eduardo Costa Cardoso, Paulo Caramelli, Leonardo Cruz de Souza

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引用次数: 0

Abstract

Background: The diagnostic value of midbrain atrophy for distinguishing behavioral variant frontotemporal dementia (bvFTD) from progressive supranuclear palsy (PSP) is unclear.

Objective: To investigate whether measures of midbrain atrophy differentiate PSP from bvFTD.

Methods: We included four groups: healthy controls (n = 19), PSP-Richardson syndrome (n = 20), bvFTD (n = 19) and Parkinson's disease (PD; n = 12). The following quantitative and qualitative measures were calculated: Hummingbird sign rating scale [HBS-RS], global midbrain atrophy [GMA], midbrain area, midbrain/pons ratio, the Magnetic Resonance Parkinsonism Index (MRPI), the MRPI 2.0 and brainstem volume.

Results: Compared to controls, PSP and bvFTD had lower values of midbrain area, HBS-RS and GMA, and higher MRPI and MRPI 2.0. HBS-RS, GMA, midbrain/pons ratio, midbrain area, MRPI, MRPI 2.0 and brainstem volume distinguished PSP from bvFTD with 73%, 67%, 75%, 83%, 71%, 69% and 82% accuracies, respectively.

Conclusions: Both quantitative and qualitative measures of midbrain atrophy provided modest accuracy in distinguishing PSP from bvFTD.

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中脑萎缩能区分进行性核上性麻痹和额颞叶痴呆吗？

背景：中脑萎缩对区分行为变异型额颞叶痴呆（bvFTD）和进行性核上性麻痹（PSP）的诊断价值尚不清楚。目的：探讨中脑萎缩指标能否区分PSP与bvFTD。方法：我们分为四组：健康对照（n = 19）、PSP-Richardson综合征（n = 20）、bvFTD （n = 19）和帕金森病(PD；n = 12)。计算以下定量和定性指标：蜂鸟体征评定量表[HBS-RS]、全脑中脑萎缩[GMA]、中脑面积、中脑/脑桥比值、磁共振帕金森病指数（MRPI）、MRPI 2.0和脑干体积。结果：与对照组相比，PSP和bvFTD的中脑面积、HBS-RS和GMA值较低，MRPI和MRPI 2.0值较高。HBS-RS、GMA、中脑/脑桥比值、中脑面积、MRPI、MRPI 2.0和脑干体积区分PSP和bvFTD的准确率分别为73%、67%、75%、83%、71%、69%和82%。结论：中脑萎缩的定量和定性方法在区分PSP和bvFTD方面都有一定的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)