Associations of modified triglyceride-glucose indices and the triglyceride/high-density lipoprotein ratio with all-cause and cause-specific mortality in the general population: an analysis of the UK biobank database.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-04-01 DOI:10.1186/s12944-025-02540-7

Zihao Zhang, Haihua Guo, Zhen Sun, Dandan Zhang, Yujing Lin, Liangyu Huang, Zexin Guo, Lan Tan

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引用次数: 0

Abstract

Background: This study investigates the associations between modified triglyceride-glucose (TyG) indices and the triglyceride-to-high-density lipoprotein (TG/HDL) ratio, which are recognized as simple surrogate indicators of insulin resistance, with all-cause and cause-specific mortality.

Methods: A cohort of 410,515 participants from the UK Biobank was analyzed. Cox proportional hazard models and restricted cubic spline regression analyses were employed to examine the relationships between the TyG index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TG/HDL ratio, and all-cause and cause-specific mortality. Structural equation modeling was employed to elucidate the associations between the TyG index, TG/HDL ratio, inflammation, metabolism, and mortality.

Results: The TyG index, TyG-WC, and TG/HDL ratio were associated with an increased risk of all-cause mortality by 3.7% (HR 1.037 [1.016, 1.059]), 0.1% (HR 1.001 [1.024, 1.031]), and 1.5% (HR 1.015 [1.006, 1.025]), respectively. Restricted cubic spline regression models revealed nonlinear trends in the TyG index, TyG-BMI, TyG-WC, and TG/HDL ratio in relation to both all-cause and cause-specific mortality (P for nonlinearity < 0.05). TyG index and TG/HDL ratio exhibited a J-shaped relationship with all-cause mortality as well as mortality from cancer, cardiovascular diseases, and respiratory diseases. Similarly, TyG-BMI demonstrated an L-shaped association with all-cause mortality and mortality due to cancer, cardiovascular diseases, and respiratory diseases. Additionally, TyG-WC was associated with a progressively increasing mortality risk once it exceeded a certain threshold. Structural equation modeling demonstrated that the TyG index and TG/HDL ratio influenced mortality through inflammation and lifestyle factors.

Conclusions: In conclusion, TyG, TyG-BMI, TyG-WC, and TG/HDL ratio are significantly associated with all-cause and cause-specific mortality in the general population.These associations appear to be linked to inflammation and lifestyle.

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修改甘油三酯-葡萄糖指数和甘油三酯/高密度脂蛋白比率与全因死亡率和原因特异性死亡率的关联：英国生物银行数据库的分析。

背景：本研究探讨了甘油三酯-葡萄糖（TyG）指数和甘油三酯-高密度脂蛋白（TG/HDL）比值与全因死亡率和病因特异性死亡率之间的关系，甘油三酯-高密度脂蛋白是胰岛素抵抗的简单替代指标。方法：对来自英国生物银行的410,515名参与者进行队列分析。采用Cox比例风险模型和限制性三次样条回归分析检验TyG指数、TyG体重指数（TyG- bmi）、TyG腰围（TyG- wc）、TG/HDL比值、全因死亡率和病因特异性死亡率之间的关系。采用结构方程模型来阐明TyG指数、TG/HDL比值、炎症、代谢和死亡率之间的关系。结果：TyG指数、TyG- wc和TG/HDL比值与全因死亡风险增加相关，分别为3.7% （HR 1.037[1.016, 1.059]）、0.1% （HR 1.001[1.024, 1.031]）和1.5% （HR 1.015[1.006, 1.025]）。限制三次样条回归模型揭示了TyG指数、TyG- bmi、TyG- wc和TG/HDL比值与全因死亡率和原因特异性死亡率之间的非线性关系（P为非线性）。结论：在一般人群中，TyG、TyG- bmi、TyG- wc和TG/HDL比值与全因死亡率和原因特异性死亡率显著相关。这些关联似乎与炎症和生活方式有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.