Relationship Between Structure and Age in Healthy Achilles Tendons

IF 2.1 3区 医学 Q2 ORTHOPEDICS
Kayla D. Seymore, Shawn L. Hanlon, Ryan T. Pohlig, Dawn M. Elliott, Karin Grävare Silbernagel
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Abstract

Age is an important factor to consider with Achilles tendon injury, as variability in tendon structure during developmental growth and aging influence lower limb function and mobility. However, the overlap in structural alterations with aging and Achilles tendon injury makes it unclear which structural changes are related to age separate from tendon pathology. The objective of this study was to determine the relationship between structure and age in healthy Achilles tendons. Healthy Achilles tendons from 389 children and adults (8–79 years) were included in this retrospective analysis. Achilles tendon morphology was assessed via B-mode ultrasound of Achilles tendon length, cross-sectional area (CSA), and thickness. Mechanical properties of Achilles tendon shear modulus and viscosity were assessed via continuous shear wave elastography. The relationship between Achilles tendon structure and age was determined using General Linear Models and White's test of heteroscedasticity (to assess for unequal variance across the age span), controlling for sex, weight, and physical activity level. Healthy free Achilles tendon length (p = 0.002), thickness (p < 0.001), CSA (p < 0.001), and viscosity (p = 0.009) increased with age, supporting age-related changes in tendon structure that may limit its capacity to store and transfer energy in older adults. Full Achilles tendon length and CSA varied across the age span (p < 0.05), suggesting the Achilles tendon undergoes natural aging processes seen with most musculoskeletal tissue. Normative data on Achilles tendon structure with age will contribute to our understanding and interpretation of Achilles tendon injury pathogenesis; aiding in the design of injury prevention and treatment strategies.

健康跟腱结构与年龄的关系
年龄是跟腱损伤的重要考虑因素,因为在发育生长和衰老过程中跟腱结构的变异性会影响下肢功能和活动能力。然而,结构变化与衰老和跟腱损伤的重叠使得不清楚哪些结构变化与年龄有关,哪些与跟腱病理无关。本研究的目的是确定健康跟腱的结构与年龄之间的关系。来自389名儿童和成人(8-79岁)的健康跟腱纳入回顾性分析。通过b超评估跟腱的长度、横截面积(CSA)和厚度。采用连续横波弹性成像技术评价跟腱剪切模量和黏度的力学性能。在控制性别、体重和体力活动水平的情况下,使用一般线性模型和White的异方差检验来确定跟腱结构与年龄之间的关系。健康游离跟腱长度(p = 0.002),厚度(p = 0.002)
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来源期刊
Journal of Orthopaedic Research®
Journal of Orthopaedic Research® 医学-整形外科
CiteScore
6.10
自引率
3.60%
发文量
261
审稿时长
3-6 weeks
期刊介绍: The Journal of Orthopaedic Research is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.
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