Does halofuginone influence regeneration after peripheral nerve injury?

IF 2.8 3区医学 Q1 ORTHOPEDICS

Journal of Orthopaedic Surgery and Research Pub Date : 2025-04-01 DOI:10.1186/s13018-025-05758-4

Muzaffer Çaydere, Ömer Şahin

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引用次数: 0

Abstract

Background: Halofuginone is an antiprotozoal drug with antifibrotic and anti-inflammatory properties. The aim of our study was to determine the effects of halofuginone on nerve recovery in sciatic nerve injury and compare it with steroid treatment.

Methods: The left sciatic nerves of Sham subjects were exposed without intervention. The nerves of trauma animals were transected and sutured. In the methylprednisolone group and in the trauma group, after nerve transection and repair, 1 mg/kg methylprednisolone per day was administered intraperitoneally for seven days; in the halofuginone group and in the trauma group, after nerve transection and repair, 0.2 mg/kg halofuginone per day was administered orally by gavage for seven days. The rats were functionally evaluated at 4 and 8 weeks through walking path analysis. Pathological-morphometric, immunostaining-quantitative, and muscle weight measurements were performed at 8 weeks.

Results: Compared with the trauma group, the methylprednisolone and the halofuginone groups had better functional outcomes (p < 0.001). Statistically significant difference was found in comparisons of the pathological and immunostaining results of the methylprednisolone and halofuginone groups (Respectively, nerve diameter (p = 0.007) and edema (P = 0.009)).

Conclusion: Halofuginone positively contributed to recovery after sciatic nerve injury.

Clinical trial number: Not applicable.

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halofuginone是否影响周围神经损伤后的再生？

背景：Halofuginone是一种具有抗纤维化和抗炎特性的抗原虫药物。本研究的目的是确定氟醌对坐骨神经损伤后神经恢复的影响，并将其与类固醇治疗进行比较。方法：对假手术患者的左侧坐骨神经进行不干预暴露。切除创伤动物的神经并缝合。甲强的松龙组和创伤组，神经横断修复后，每天腹腔注射甲强的松龙1 mg/kg，连用7天；halfuginone组和创伤组神经横断修复后，每天灌胃0.2 mg/kg halfuginone，连用7 d。在第4周和第8周通过步行路径分析评估大鼠的功能。8周时进行病理形态学、免疫染色定量和肌肉重量测量。结果：与创伤组相比，甲基强的松龙组和氟化氟酮组功能预后较好(p)。结论：氟化氟酮对坐骨神经损伤后的恢复有积极作用。临床试验号：不适用。

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来源期刊

Journal of Orthopaedic Surgery and Research ORTHOPEDICS-

CiteScore

4.10

自引率

7.70%

发文量

494

审稿时长

>12 weeks

期刊介绍： Journal of Orthopaedic Surgery and Research is an open access journal that encompasses all aspects of clinical and basic research studies related to musculoskeletal issues. Orthopaedic research is conducted at clinical and basic science levels. With the advancement of new technologies and the increasing expectation and demand from doctors and patients, we are witnessing an enormous growth in clinical orthopaedic research, particularly in the fields of traumatology, spinal surgery, joint replacement, sports medicine, musculoskeletal tumour management, hand microsurgery, foot and ankle surgery, paediatric orthopaedic, and orthopaedic rehabilitation. The involvement of basic science ranges from molecular, cellular, structural and functional perspectives to tissue engineering, gait analysis, automation and robotic surgery. Implant and biomaterial designs are new disciplines that complement clinical applications. JOSR encourages the publication of multidisciplinary research with collaboration amongst clinicians and scientists from different disciplines, which will be the trend in the coming decades.