The effects of Dendropanax morbiferus on cognitive function and cerebral cortical thickness: A randomized, double-blind, placebo-controlled trial.

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Chaewon Suh, Shinhye Kim, Yoonji Joo, Eunji Ha, Youngeun Shim, Hyeonji Lee, Yejin Kim, Sujung Yoon
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引用次数: 0

Abstract

BackgroundEarly intervention for subjective cognitive decline (SCD) is becoming increasingly important to prevent progression to Alzheimer's disease (AD). Despite the promising results observed in animal models of AD, the neuroprotective and cognitive-enhancing effects of Dendropanax morbiferus (DM) still need to be evaluated in individuals with cognitive decline.ObjectiveThis 12-week, randomized, double-blind, placebo-controlled trial assessed the effects of DM leaf extracts on cognitive function in 85 individuals with SCD (KCT0006329, registered on July 7, 2021).MethodsParticipants were randomly assigned to either the DM (n = 43) or the placebo (n = 42) group. Cognitive functions, including attention and memory, were assessed at baseline, 8 weeks, and 12 weeks. High-resolution T1-weighted magnetic resonance imaging was performed at the beginning and end of the study to evaluate cortical thickness. Changes in cognition and cortical thickness and their associations were evaluated.ResultsThe results demonstrated significant improvements in attention (p = 0.014), memory (p = 0.037), and global cognitive function (p = 0.001) in the DM group compared to the placebo group, accompanied by increased cortical thickness in the left lingual gyrus/cuneus (corrected p < 0.05). Furthermore, in the DM group, increased cortical thickness in this region was correlated with both memory (r = 0.422, p = 0.016) and global cognitive functions (r = 0.471, p = 0.007). DM was well-tolerated, with no adverse events reported.ConclusionsThese findings suggest that DM may possess cognitive-enhancing properties for individuals with SCD.

病态石斛对认知功能和大脑皮质厚度的影响:一项随机、双盲、安慰剂对照试验。
背景:主观认知能力下降(SCD)的干预对于预防阿尔茨海默病(AD)的进展变得越来越重要。尽管在AD的动物模型中观察到有希望的结果,但在认知能力下降的个体中,仍需要评估病态石斛(DM)的神经保护和认知增强作用。这项为期12周的随机、双盲、安慰剂对照试验评估了DM叶提取物对85例SCD患者认知功能的影响(KCT0006329,于2021年7月7日注册)。方法将受试者随机分为DM组(n = 43)和安慰剂组(n = 42)。认知功能,包括注意力和记忆,分别在基线、8周和12周进行评估。在研究开始和结束时进行高分辨率t1加权磁共振成像以评估皮质厚度。评估认知和皮质厚度的变化及其相关性。结果与安慰剂组相比,DM组在注意力(p = 0.014)、记忆力(p = 0.037)和整体认知功能(p = 0.001)方面均有显著改善,并伴有左侧舌回/楔叶皮质厚度(p = 0.422, p = 0.016)和整体认知功能(r = 0.471, p = 0.007)的增加。DM耐受性良好,无不良事件报道。结论DM可能对SCD患者具有认知增强作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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