Systematic evaluation of vitamin D and the risk of breast cancer development.

Abstract

Backgroud: Tumor is a major public health problem worldwide and poses a serious threat to human life and health. Vitamin D deficiency increases the risk of developing tumors.

Summary: Epidemiological evidence supports the anti-tumor effect of vitamin D mainly comes from the binding of its active metabolites and vitamin D receptor（VDR） to play relevant biological functions. The meta-analysis generally reported that high vitamin D status was a protective factor for breast cancer (BC). In addition, the relationship of vitamin D-related gene polymorphisms with the tumor and the relationship between vitamin D levels and tumor occurrence and risk have also attracted much attention.

Key messages: This paper reviews the research progress of vitamin D metabolism, potential anticancer mechanisms in the tumor microenvironment and its relationship with the risk of different tumors, and explores the relationship between vitamin D-related gene polymorphisms and tumors, providing theoretical reference for primary prevention of future tumors.