Perception of infertility risk vs. objective fertility status in males exposed to alkylating agents but not radiation therapy: a report from the St. Jude Lifetime (SJLIFE) cohort study.

IF 3.1 2区 医学 Q2 ONCOLOGY
Megan E Ware, Raymond K We, William H Kutteh, Rachel T Webster, Angela Delaney, Christine Yu, Kyla Shelton, DeoKumar Srivastava, Siddhant Taneja, Yadav Sapkota, Zhaoming Wang, Melissa M Hudson, John Lucas, Gregory T Armstrong, Kirsten K Ness, Daniel M Green
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引用次数: 0

Abstract

Purpose: This study aimed to characterize associations between male childhood cancer survivors' perception of infertility risk and objective fertility status and to identify factors contributing to risk perception.

Methods: Participants were from SJLIFE, exposed to alkylating agents but not radiation, and completed a Men's Health Questionnaire (MHQ) and semen analysis. Samples were obtained following the 2010 World Health Organization Guidelines, and classified as azoospermic (0 sperm), oligospermic (> 0 and < 15 million sperm/ml), or normospermic (≥ 15 million sperm/ml). Participants were classified as at minimally or high/significantly increased risk for infertility according to the Pediatric Initiative Network (PIN) criteria. Perception of infertility risk was assessed via self-report where survivors indicated the following: (1) more risk than peers without cancer history, (2) less risk, or (3) equal risk, as well as factors contextualizing perceived risk. Chi-squared tests or Fishers' exact tests assessed differences in variables of interest.

Results: Among 238 participants (age 27 ± 6 years, 85% NH White, 47% survivors of leukemia), 58% perceived increased infertility risk than peers without cancer history, 29% equal risk, and 13% less risk. A larger proportion of survivors with azoospermia perceived higher risk than other groups (74%) (p = 0.01). No differences were observed in risk perception by PIN criteria. No differences were observed by sperm concentration category or PIN criteria in factors contextualizing perceived risk.

Conclusions: Male survivors not exposed to radiation in the SJLIFE cohort are generally aware of their infertility risk.

Implications for cancer survivors: Male survivors should seek continued follow-up care regarding fertility and information on risk from reputable sources.

接受烷基化剂而非放射治疗的男性不孕风险感知与客观生育状况:St. Jude Lifetime (SJLIFE)队列研究的一份报告
目的:本研究旨在描述男性儿童癌症幸存者对不育风险的感知与客观生育状况之间的关系,并确定影响风险感知的因素。方法:参与者来自SJLIFE,暴露于烷基化剂而非辐射,并完成了男性健康问卷(MHQ)和精液分析。根据2010年世界卫生组织指南获得样本,并将其分类为无精子(0精子)和少精子(>)。结果:在238名参与者(年龄27±6岁,85%为白种人,47%为白血病幸存者)中,58%的人认为不孕风险比没有癌症病史的同龄人增加,29%的风险相等,13%的风险更低。无精子症幸存者的风险高于其他组(74%)(p = 0.01)。在PIN标准的风险感知上没有观察到差异。精子浓度类别或PIN标准在影响感知风险的因素方面没有观察到差异。结论:SJLIFE队列中未暴露于辐射的男性幸存者通常意识到他们的不育风险。对癌症幸存者的启示:男性幸存者应该从信誉良好的来源寻求关于生育和风险信息的持续随访护理。
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来源期刊
CiteScore
7.00
自引率
10.80%
发文量
149
审稿时长
>12 weeks
期刊介绍: Cancer survivorship is a worldwide concern. The aim of this multidisciplinary journal is to provide a global forum for new knowledge related to cancer survivorship. The journal publishes peer-reviewed papers relevant to improving the understanding, prevention, and management of the multiple areas related to cancer survivorship that can affect quality of care, access to care, longevity, and quality of life. It is a forum for research on humans (both laboratory and clinical), clinical studies, systematic and meta-analytic literature reviews, policy studies, and in rare situations case studies as long as they provide a new observation that should be followed up on to improve outcomes related to cancer survivors. Published articles represent a broad range of fields including oncology, primary care, physical medicine and rehabilitation, many other medical and nursing specialties, nursing, health services research, physical and occupational therapy, public health, behavioral medicine, psychology, social work, evidence-based policy, health economics, biobehavioral mechanisms, and qualitative analyses. The journal focuses exclusively on adult cancer survivors, young adult cancer survivors, and childhood cancer survivors who are young adults. Submissions must target those diagnosed with and treated for cancer.
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