Oncocytic pituicytoma in a patient with Cushing's disease: a case report and narrative literature review.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1487120

Jing Li, Shuaiming Chen, Huiwen Tan, Yerong Yu, Ying Tang, Bowen Cai, Jianwei Li

{"title":"Oncocytic pituicytoma in a patient with Cushing's disease: a case report and narrative literature review.","authors":"Jing Li, Shuaiming Chen, Huiwen Tan, Yerong Yu, Ying Tang, Bowen Cai, Jianwei Li","doi":"10.3389/fendo.2025.1487120","DOIUrl":null,"url":null,"abstract":"Background: Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the World Health Organization (WHO) classified four types of tumors originating from the posterior pituitary: traditional pituicytoma, oncocytic pituicytoma, granular pituicytoma, and ependymal pituicytoma. To our knowledge, only one subject with coexistence of Cushing's disease and oncocytic pituicytoma (spindle cell oncocytoma) has been reported, but the clinical features of this patient were not described in detail.Case presentation: We presented a case of a patient with Cushing's syndrome and a pituitary mass. Transsphenoidal surgery was performed, and pathologic examination revealed two distinct tumors: a corticotroph adenoma with a diameter of less than 2 mm and a larger oncocytic pituicytoma. Post-surgery serum cortisol was 51 nmol/L, indicating complete remission. Corticotroph adenoma or corticotroph hyperplasia was identified after surgery in less than half of the subjects with Cushing's disease and PPT.Conclusions: Our study indicates that Cushing's disease in patients with PPT may be caused by the existence of collision lesions, with corticotroph adenoma or hyperplasia being difficult to detect due to their small dimensions.","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1487120"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958162/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fendo.2025.1487120","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the World Health Organization (WHO) classified four types of tumors originating from the posterior pituitary: traditional pituicytoma, oncocytic pituicytoma, granular pituicytoma, and ependymal pituicytoma. To our knowledge, only one subject with coexistence of Cushing's disease and oncocytic pituicytoma (spindle cell oncocytoma) has been reported, but the clinical features of this patient were not described in detail.

Case presentation: We presented a case of a patient with Cushing's syndrome and a pituitary mass. Transsphenoidal surgery was performed, and pathologic examination revealed two distinct tumors: a corticotroph adenoma with a diameter of less than 2 mm and a larger oncocytic pituicytoma. Post-surgery serum cortisol was 51 nmol/L, indicating complete remission. Corticotroph adenoma or corticotroph hyperplasia was identified after surgery in less than half of the subjects with Cushing's disease and PPT.

Conclusions: Our study indicates that Cushing's disease in patients with PPT may be caused by the existence of collision lesions, with corticotroph adenoma or hyperplasia being difficult to detect due to their small dimensions.

查看原文本刊更多论文

背景：垂体后叶肿瘤（PPTs）极为罕见，迄今报道的病例不到400例。2022 年，世界卫生组织（WHO）将源自垂体后叶的肿瘤分为四种类型：传统垂体细胞瘤、肿瘤细胞垂体细胞瘤、颗粒垂体细胞瘤和上皮垂体细胞瘤。据我们所知，目前仅有一例库欣病与肿瘤性垂体细胞瘤（纺锤形细胞肿瘤）并存的病例，但并未详细描述该患者的临床特征：我们介绍了一例患有库欣综合征和垂体肿块的患者。患者接受了经蝶窦手术，病理检查发现了两个不同的肿瘤：一个是直径小于 2 毫米的皮质腺瘤，另一个是较大的肿瘤性垂体细胞瘤。手术后血清皮质醇为 51 nmol/L，表明病情完全缓解。在不到一半的库欣病和 PPT 患者中，手术后发现了皮质营养腺瘤或皮质营养增生：我们的研究表明，PPT 患者的库欣病可能是由碰撞病变引起的，皮质腺瘤或皮质增生因其体积小而难以发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.