Serum BDNF, depressive symptoms, sleep quality, and cognitive function: a study on their impact and predictive value for suicidal ideation in bipolar depressive disorder patients.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-04-02 DOI:10.1007/s00406-025-01997-y

Dongxia Li, Li Ma, Yingying Feng

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引用次数: 0

Abstract

Objective: This study aims to investigate the factors influencing suicidal ideation in patients with bipolar depressive disorder (BDD), focusing primarily on cognitive function, brain-derived neurotrophic factor (BDNF), sleep quality, and depressive symptoms.

Methods: A total of 126 patients with depressive episodes of bipolar disorder and 38 healthy controls were recruited for this study. Participants were divided into suicidal ideation and non-suicidal ideation groups based on the Beck Scale for Suicide Ideation-Chinese Version (BSI-CV). Depressive symptoms were assessed using the 24-item Hamilton Rating Scale for Depression (HAMD-24), and sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Cognitive function was measured using the Chinese version of the MATRICS Consensus Cognitive Battery (MCCB), and serum BDNF levels were determined.

Results: 24.6% of the patients exhibited suicidal ideation. High depression scores and poor sleep quality were identified as risk factors, whereas good cognitive function and higher levels of BDNF served as protective factors. Receiver Operating Characteristic (ROC) analysis revealed that serum BDNF, depressive symptoms, sleep quality, and cognitive function have significant predictive value, with a combined use of these four indicators yielding even better predictive results.

Conclusion: Serum BDNF levels, depression scores, sleep quality scores, and cognitive function scores can be used as predictive indicators for suicidal ideation in BDD patients. The combined use of these four indicators provides optimal predictive efficacy.

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血清BDNF、抑郁症状、睡眠质量和认知功能：对双相抑郁症患者自杀意念的影响和预测价值的研究

目的：探讨双相抑郁障碍（BDD）患者自杀意念的影响因素，主要关注认知功能、脑源性神经营养因子（BDNF）、睡眠质量和抑郁症状。方法：本研究共招募了126例双相情感障碍抑郁发作患者和38例健康对照者。采用贝克自杀意念量表（BSI-CV）将被试分为有自杀意念组和无自杀意念组。采用24项汉密尔顿抑郁量表（HAMD-24）评估抑郁症状，采用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。使用中文版的matrix共识认知电池（MCCB）测量认知功能，并测定血清BDNF水平。结果：24.6%的患者表现出自杀意念。抑郁得分高和睡眠质量差被认为是危险因素，而良好的认知功能和较高水平的BDNF是保护因素。受试者工作特征（ROC）分析显示，血清BDNF、抑郁症状、睡眠质量和认知功能具有显著的预测价值，结合使用这四项指标可以获得更好的预测结果。结论：血清BDNF水平、抑郁评分、睡眠质量评分、认知功能评分可作为BDD患者自杀意念的预测指标。这四项指标的联合使用提供了最佳的预测效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.