{"title":"Biomarkers associated with the diagnosis and prognosis of <i>Mycoplasma pneumoniae</i> pneumonia in children: a review.","authors":"Lele Ding, Yonghong Jiang","doi":"10.3389/fcimb.2025.1552144","DOIUrl":null,"url":null,"abstract":"<p><p>Community-acquired pneumonia (CAP) is a major cause of death in children, and <i>Mycoplasma pneumoniae</i> (MP) is the main pathogen of CAP in children in China. Although <i>Mycoplasma pneumoniae</i> pneumonia (MPP) is usually a self-limiting disease, many children develop multiple complications due to drug resistance or untimely diagnosis and treatment, and may even progress to severe MPP or refractory MPP with a poor prognosis. It is important to explore the value of biomarkers that can be used in clinical practice to assess the severity of pneumonia and assist in clinical decision making. In this article, we searched the literature in the last four years to review the roles of various types of biomarkers in MPP and the associated clinical predictive models, with the aim of helping pediatricians to understand the evaluation indexes related to MPP in children other than microbiology.</p>","PeriodicalId":12458,"journal":{"name":"Frontiers in Cellular and Infection Microbiology","volume":"15 ","pages":"1552144"},"PeriodicalIF":4.6000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958718/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cellular and Infection Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcimb.2025.1552144","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Community-acquired pneumonia (CAP) is a major cause of death in children, and Mycoplasma pneumoniae (MP) is the main pathogen of CAP in children in China. Although Mycoplasma pneumoniae pneumonia (MPP) is usually a self-limiting disease, many children develop multiple complications due to drug resistance or untimely diagnosis and treatment, and may even progress to severe MPP or refractory MPP with a poor prognosis. It is important to explore the value of biomarkers that can be used in clinical practice to assess the severity of pneumonia and assist in clinical decision making. In this article, we searched the literature in the last four years to review the roles of various types of biomarkers in MPP and the associated clinical predictive models, with the aim of helping pediatricians to understand the evaluation indexes related to MPP in children other than microbiology.
期刊介绍：
Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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