Serum potassium level is associated with serum neurofilament light chain in American adult population: a cross-sectional analysis of the 2013-2014 National Health and Nutrition Examination Survey.
Yingming Kong, Yanghao Tai, Bin Chen, Chunzheng Li, Hao Chen, Liang Shi
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引用次数: 0
Abstract
Objective: Serum neurofilament light chain (sNfL) is one of the most sensitive diagnostic biomarkers for a variety of neurodegenerative pathologies. Potassium, an essential electrolyte, plays a critical role in maintaining neuronal health and the proper functioning of the central nervous system (CNS). The aim of our research was to investigate the association between serum potassium level and sNfL levels.
Methods: Based on the National Health and Nutrition Examination Survey (NHANES) database, we analyzed data from the 2013 to 2014 NHANES. Serum potassium concentrations were measured via ion-selective electrode (ISE) technology. The levels of sNfL were measured using a sensitive immunoassay developed by Siemens Healthineers. Our researcher analyzed the association between potassium level in serum and sNfL in American persons using multivariate logistic regression analysis and smoothed curve fitting. The consistency of these results was examined in various population subgroups.
Results: A total of 1,670 participants were involved in our research, including 872 women (50.5%) and 798 men (49.5%). The median serum potassium concentration was 4.0 mmol/L and the median sNfL was 12.3 pg/ml. After adjusting for potential confounders in the full model, individuals with higher serum potassium concentrations had higher sNfL levels (Q3 vs. Q1, β = 2.86, 95% CI: 0.33-5.39, P = 0.027). There was a non-linear positive dose-response association between higher serum potassium concentrations and sNfL levels (P for non-linearity = 0.028). Based on the results of stratified analysis, the relationship was stronger in the low- and middle-income group, non-drinking and non-physical activity participants, and participants with hypertension and diabetes.
Interpretation: In the cohort of American adults, a greater serum potassium concentration was linked to a higher sNfL. However, causality still needs to be further verified.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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