{"title":"Chronic actinic dermatitis - a familial link?","authors":"Usamah M Afzal, Donna Parkin, Jean Ayer","doi":"10.1093/ced/llaf154","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic actinic dermatitis (CAD) is an inflammatory, immune-mediated photodermatoses that is characterised by erythematous, pruritic, lichenified plaques affecting photo-exposed areas of the body. The pathogenesis of CAD remains unknown with many postulated theories in the literature. The predominant hypothesis suggests a delayed type IV hypersensitivity reaction caused by photosensitive skin antigens - similar in disease process to allergic contact dermatitis (ACD).1 Despite current evidence suggesting no familial inheritance we present the first reported cases of CAD affecting three members of the same family, with increasing severity in each subsequent generation (i.e., two generations), strengthening the case for potential genetic predisposition.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ced/llaf154","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Chronic actinic dermatitis (CAD) is an inflammatory, immune-mediated photodermatoses that is characterised by erythematous, pruritic, lichenified plaques affecting photo-exposed areas of the body. The pathogenesis of CAD remains unknown with many postulated theories in the literature. The predominant hypothesis suggests a delayed type IV hypersensitivity reaction caused by photosensitive skin antigens - similar in disease process to allergic contact dermatitis (ACD).1 Despite current evidence suggesting no familial inheritance we present the first reported cases of CAD affecting three members of the same family, with increasing severity in each subsequent generation (i.e., two generations), strengthening the case for potential genetic predisposition.
期刊介绍：
Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.
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