Comparative Study of MiroCam MC2000 and PillCam SB3 in Detecting Small Bowel Bleeding: A Multicenter Prospective Randomized Crossover Study.

IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gut and Liver Pub Date : 2025-04-01 DOI:10.5009/gnl240541
Ji Eun Kim, Eun Ran Kim, Jae Jun Park, Kyeong Ok Kim, Yehyun Park, Young Joo Yang, Hyun Joo Jang
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引用次数: 0

Abstract

Background/aims: The MiroCam MC2000 (MC2000) is a double-tip capsule with a camera on each side. It is designed to provide more extensive visualization of the small bowel mucosa, potentially reducing the chance of missing lesions. This study aimed to compare the detection rates for lesions in the ampulla of Vater (AoV) and the small bowel of the MC2000 and the PillCam SB3 (SB3) for patients with suspected small bowel bleeding.

Methods: This prospective, multicenter, randomized crossover trial compared the lesion detection capabilities of the MC2000 and SB3 capsules, ingested one hour apart by patients with suspected small bowel bleeding. The primary outcome was the detection of lesions in the AoV, while the secondary outcome was the assessment of the detection of P1 and P2 lesions, known underlying causes of small bowel bleeding.

Results: There was no significant difference in AoV lesion detection rates between the devices. However, MC2000 demonstrated significantly greater detection of red spots in patients with visible bleeding (p=0.018) and tended to detect a greater number of small bowel lesions, including P2 lesions. Minor complications included device stasis, with fewer incidents with the MC2000 than with the SB3, and one instance of small bowel retention due to ulcers.

Conclusions: The MC2000's dual-camera system appears to enhance the detection of small bowel lesions over the SB3, especially for more important lesions. These findings suggest that the MC2000 may offer superior diagnostic capabilities for patients with suspected small bowel bleeding, potentially leading to better clinical outcomes (this trial registered KCT0005591).

背景/目的:MiroCam MC2000(MC2000)是一种双头胶囊,两侧各有一个摄像头。其设计目的是为小肠粘膜提供更广泛的可视化,从而降低遗漏病变的几率。本研究旨在比较 MC2000 和 PillCam SB3(SB3)对疑似小肠出血患者的 Vater ampulla(AoV)和小肠病变的检出率:这项前瞻性、多中心、随机交叉试验比较了 MC2000 和 SB3 胶囊的病变检测能力,疑似小肠出血患者服用 MC2000 和 SB3 胶囊的时间间隔为一小时。主要结果是检测出AoV中的病变,次要结果是评估P1和P2病变的检测情况,P1和P2病变是小肠出血的已知潜在原因:结果:两种设备的AoV病变检出率无明显差异。然而,MC2000 对可见出血患者红点的检出率明显更高(P=0.018),而且往往能检出更多的小肠病变,包括 P2 病变。轻微并发症包括器械瘀血,MC2000 比 SB3 的发生率更低,还有一次因溃疡导致小肠滞留:结论:与 SB3 相比,MC2000 的双摄像头系统似乎提高了对小肠病变的检测能力,尤其是对重要病变的检测能力。这些研究结果表明,MC2000 可为疑似小肠出血患者提供更出色的诊断能力,可能会带来更好的临床效果(本试验注册号为 KCT0005591)。
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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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