Mitochondrial heat production: the elephant in the lab….

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-03-31 DOI:10.1016/j.tibs.2025.03.002

Pierre Rustin, Howard T Jacobs, Mügen Terzioglu, Paule Bénit

引用次数: 0

Abstract

It has long been established that heat represents a major part of the energy released during the oxidation of mitochondrial substrates. However, with a few exceptions, the release of heat is rarely mentioned other than as being produced at the expense of ATP, without having any specific function. Here, after briefly surveying the literature on mitochondrial heat production, we argue for its cellular and organismal importance, sharing our opinions as to what could account for this unbalanced portrayal of mitochondrial energy transactions.

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线粒体产热：实验室里的大象....

热是线粒体底物氧化过程中释放的能量的主要部分，这一点早已得到证实。然而，除了少数例外，热量的释放很少被提及，而是以ATP为代价产生的，没有任何特定的功能。在这里，简要调查了关于线粒体产热的文献后，我们认为其细胞和有机体的重要性，分享我们的观点，什么可以解释线粒体能量交易的这种不平衡的描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.