Evaluation of Effects of a High-Protein Hypocaloric Diet on Body Composition and Cardio-Metabolic Factors in Women with Polycystic Ovary Syndrome and Overweight or Obesity.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Fang Wang, Wei Wei, Peng Ju Liu
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Abstract

Background: The optimal composition of a hypocaloric diet for women with polycystic ovary syndrome (PCOS) remains uncertain. The aim of this study was to evaluate and compare the impacts of a hypocaloric high-protein diet (HPD) versus an isocaloric conventional calorie-restricted diet (CRD) with normal protein intake on the body composition and biochemical profiles of women diagnosed with PCOS combined with overweight or obesity.

Methods: This was a dietary intervention study evaluating the effects of two types of diets on women with PCOS who initiated weight loss independently at the Clinical Nutrition Clinic of Peking Union Medical College Hospital from March 2023 to March 2024 was carried out. Specifically, the records of 72 women with PCOS who were overweight or obese and underwent a 3-month weight management program were examined in a retrospective manner. The hypocaloric dietary intervention was adopted to achieve weight reduction, with either HPD or CRD. Body composition, serum lipids, glucose, insulin, and total testosterone (TT) were evaluated at baseline and post-intervention, and the differences were compared between and within groups.

Results: Both groups achieved significant weight loss, with the HPD group losing an average of -8.9 ± 4.6 kg and the CRD group losing -10.0 ± 9.4 kg, without a significant difference between them (P > 0.05). However, the HPD was superior in preserving fat-free mass (FFM) and fat-free mass index (FFMI), with losses of -1.5 ± 1.6 kg and -0.7 ± 1.1 kg/m², respectively, compared to the CRD group's losses of -4.4 ± 4.2 kg and -2.1 ± 1.9 kg/m² (P < 0.01). Additionally, the HPD group showed a more significant reduction in body fat percentage (-5.3 ± 3.3% vs -3.2 ± 4.5%, P < 0.05). Biochemical indicators were comparable in both groups.

Conclusion: Compared to an isocaloric standard-protein CRD, the dietary intervention with a HPD appears to be more helpful in preserving FFM in women with PCOS during a short-term weight loss program. Further well-designed trials are needed to verify our findings.

评估高蛋白低热量饮食对多囊卵巢综合征和超重或肥胖妇女身体组成和心脏代谢因素的影响
背景:对于患有多囊卵巢综合征(PCOS)的女性,低热量饮食的最佳组成仍然不确定。本研究的目的是评估和比较低热量高蛋白饮食(HPD)与等热量常规热量限制饮食(CRD)对诊断为多囊卵巢综合征合并超重或肥胖女性的身体成分和生化特征的影响。方法:对2023年3月至2024年3月在北京协和医院临床营养门诊独立开始减肥的PCOS女性进行两种饮食干预研究。具体来说,72名超重或肥胖的多囊卵巢综合征女性患者接受了为期3个月的体重管理计划,并以回顾性的方式进行了检查。采用低热量饮食干预来实现体重减轻,无论是HPD还是CRD。在基线和干预后评估体成分、血脂、葡萄糖、胰岛素和总睾酮(TT),并比较组间和组内差异。结果:两组体重均有显著下降,HPD组平均体重下降-8.9±4.6 kg, CRD组平均体重下降-10.0±9.4 kg,两者差异无统计学意义(P < 0.05)。然而,与CRD组的-4.4±4.2 kg和-2.1±1.9 kg/m²相比,HPD组在保持无脂质量(FFM)和无脂质量指数(FFMI)方面表现更佳,分别为-1.5±1.6 kg和-0.7±1.1 kg/m²(P < 0.01)。此外,HPD组体脂率降低更为显著(-5.3±3.3% vs -3.2±4.5%,P < 0.05)。两组生化指标具有可比性。结论:与等热量标准蛋白CRD相比,饮食干预与HPD似乎更有助于在短期减肥计划中保留PCOS女性的FFM。需要进一步精心设计的试验来验证我们的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
5.90
自引率
6.10%
发文量
431
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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