Investigating the effects of different herbal preparations, 5-hydroxytryptophan and involuntary exercise on affective bias modification in male Lister Hooded rats.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Behavioural Pharmacology Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI:10.1097/FBP.0000000000000826
Justyna K Hinchcliffe, Sarah A Stuart, Emma S J Robinson
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引用次数: 0

Abstract

Mood disorders are a prevalent global health concern with natural health products, including herbal supplements, an increasingly popular choice as an alternative or complementary therapy. Despite their widespread use, few studies have tested the clinical efficacy of natural health products or explored their underlying mechanisms in animal models. Modification of affective biases has been linked to mood in humans and animal models and may provide insights into potential antidepressant effects. In this study, we used a translational rodent model of affective bias modification to investigate the effects of five commonly used supplements: Hypericum perforatum , that is, St. John's Wort (SJW), Mucuna pruriens , Rhodiola rosea root extract, Valerian root extract and 5-hydroxytryptophan. Exercise is also thought to improve mood disorders, but clinical studies reveal mixed results therefore we also tested the effect of involuntary exercise on affective biases. In separate experiments, male Lister Hooded rats were acutely treated with SJW, Mucuna pruriens , Rhodiola rosea root extract, Valerian root extract and 5-hydroxytryptophan, or underwent an involuntary exercise manipulation. Our results showed a significant positive affective bias following treatment with SJW, whilst the involuntary exercise induced a negative affective bias in rats. No effects were found following the other acute treatments. These data suggest SJW has similar effects in terms of affective bias modification as conventional antidepressants. The negative affective bias observed with involuntary exercise suggests the animals experience a negative affective state and suggests exercise-based therapy may be less effective if the patient perceives this as involuntary.

研究不同草药制剂、5-羟色氨酸和不自主运动对雄性李斯特兜帽大鼠情感偏见修正的影响。
情绪障碍是全球普遍关注的健康问题,天然保健产品,包括草药补充剂,作为替代或补充治疗的日益流行的选择。尽管它们被广泛使用,但很少有研究测试天然保健品的临床疗效或在动物模型中探索其潜在机制。在人类和动物模型中,情感偏见的改变与情绪有关,并可能为潜在的抗抑郁作用提供见解。在这项研究中,我们使用了一种情感偏差修正的转化啮齿动物模型来研究五种常用补充剂的效果:贯叶连翘,即圣约翰草(SJW), Mucuna pruriens,红景天玫瑰根提取物,缬草根提取物和5-羟色氨酸。运动也被认为可以改善情绪障碍,但临床研究显示的结果好坏参半,因此我们也测试了非自愿运动对情感偏见的影响。在单独的实验中,雄性李斯特兜帽大鼠被急性治疗SJW,粘草,红景天根提取物,缬草根提取物和5-羟色氨酸,或进行非自愿运动操作。我们的研究结果显示,在SJW治疗后,大鼠出现了显著的积极情感偏差,而不自主运动诱导了大鼠的消极情感偏差。其他急性治疗后未见效果。这些数据表明,SJW在改变情感偏倚方面与传统抗抑郁药具有相似的效果。在非自愿运动中观察到的消极情感偏差表明,动物经历了一种消极的情感状态,如果患者认为这是非自愿的,那么基于运动的治疗可能效果较差。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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