Guilt and shame and its relation to oxytocin in patients with depression and alcohol addiction.

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2025-04-02 DOI:10.1186/s12888-025-06762-y

Paraskevi Mavrogiorgou, Patric Dalhoff, Georg Juckel

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Abstract

Backround: Guilt and shame are important and universal social emotions that fundamentally shape the way people interact with each other. Mental illness such as depressive disorder (DD) or alcohol addiction (AA) is therefore often related to pronounced dysfunctional feelings of shame and guilt. Oxytocin has been suggested to play an important role in socially and morally associated emotions such as shame and guilt.

Methods: A total of 85 participants (41 women and 44 men) were clinically investigated, including shame and guilty proneness. To assess the proneness for guilt and shame, the IGQ, the SCV scale, TOSCA, and SHAME were used.

Results: Patients with DD showed a maladaptive guilt and shame profile, characterized by increased interpersonal feelings of guilt and increased proneness of shame. Patients with AA were characterized by the lowest reserve and antidelophilic attitude. Oxytocin values were lowest in the patients with AA compared to the two other groups, but not related to guilt and shame.

Conclusion: The proneness to maladaptive guilt and shame of mental disorders appears to be less dependent on specific disease aspects than on individual characteristics. Dimensions such as guilt and shame should be more implemented in psychotherapy.

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背景：内疚和羞愧是重要而普遍的社会情绪，从根本上决定了人与人之间的互动方式。因此，抑郁障碍（DD）或酗酒成瘾（AA）等精神疾病往往与明显的羞耻感和内疚感功能失调有关。催产素被认为在羞愧和内疚等与社会和道德相关的情绪中发挥着重要作用：共对 85 名参与者（41 名女性和 44 名男性）进行了临床调查，包括羞耻感和内疚感。为了评估内疚感和羞愧感，我们使用了 IGQ、SCV 量表、TOSCA 和 SHAME：结果：DD 患者表现出适应不良的内疚感和羞耻感，其特点是人际内疚感和羞耻感增加。AA患者的储备和反亲友态度最低。与其他两组患者相比，AA 患者的催产素值最低，但与内疚感和羞耻感无关：结论：精神障碍患者的内疚感和羞耻感似乎与特定疾病的关系不大，而与个体特征有关。在心理治疗中应更多地考虑内疚感和羞耻感等因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.