The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-04-02 DOI:10.1126/sciadv.adt1083

Rongtao Jiang, Paul Geha, Matthew Rosenblatt, Yunhe Wang, Zening Fu, Maya Foster, Wei Dai, Vince D. Calhoun, Jing Sui, Marisa N. Spann, Dustin Scheinost

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Abstract

Chronic pain conditions frequently coexist and share common genetic vulnerabilities. Despite evidence showing associations between pain and depression, the additive effect of co-occurring pain conditions on depression risk and the underlying mechanisms remain unclear. Leveraging data from 431,038 UK Biobank participants with 14-year follow-up, we found a significantly increased risk of depression incidence in individuals reporting pain, irrespective of body site or duration (acute or chronic), compared with pain-free individuals. The depression risk increased with the number of co-occurring pain sites. Mendelian randomization supported potential causal inference. We constructed a composite pain score by combining individual effects of acute or chronic pain conditions across eight body sites in a weighted manner. We found that depression risks increased monotonically in parallel with composite pain scores. Moreover, some inflammatory markers, including C-reactive protein, partially mediated the association between composite pain scores and depression risk. Considering the high prevalence of comorbid depression and pain, pain screening may help identify high-risk individuals for depression.

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并发疼痛对抑郁症累积效应的炎症和遗传机制

慢性疼痛经常共存，并具有共同的遗传脆弱性。尽管有证据表明疼痛和抑郁之间存在关联，但同时发生的疼痛状况对抑郁风险的叠加效应及其潜在机制仍不清楚。通过对431,038名英国生物银行参与者进行14年随访的数据，我们发现，与无痛个体相比，报告疼痛的个体，无论身体部位或持续时间（急性或慢性），抑郁发生率显著增加。抑郁风险随着同时出现疼痛部位的数量增加而增加。孟德尔随机化支持潜在的因果推理。我们以加权的方式将八个身体部位的急性或慢性疼痛状况的个体影响结合起来，构建了一个复合疼痛评分。我们发现抑郁风险单调增加与复合疼痛评分平行。此外，一些炎症标志物，包括c反应蛋白，部分介导了复合疼痛评分和抑郁风险之间的关联。考虑到抑郁症和疼痛并存的高患病率，疼痛筛查可能有助于识别抑郁症的高危人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.