Role of miRNA polymorphisms on male and female infertility and recurrent implantation failure

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-04-02 DOI:10.1111/jog.16281

Reza Alibakhshi, Masoud Soleimani, Kheirollah Yari, Amir Ali Kalhori, Mohsen Karami, Mohammad Reza Kalhori

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引用次数: 0

Abstract

Purpose

MiRNAs regulate gene expression, impacting reproductive health, such as infertility and implantation failure. This study investigated the association between miRNA polymorphisms and male infertility (azoospermia, oligospermia), female infertility (endometriosis), and recurrent implantation failure in IVF.

Methods

In order to find relevant articles, a search was conducted in PubMed, WOS, Scopus, and the Cochrane Library databases using Mesh terms and Entry terms with the keywords (miRNA OR microRNA polymorphism) AND (abortion OR miscarriage OR infertility OR sterility OR pregnancy loss OR implantation failure).

Results

The study revealed miRNA polymorphisms linked to a higher risk of male and female infertility and repeated implantation failure in IVF. These results underscore the significance of genetic variations in miRNAs in developing reproductive issues and the promise of personalized treatment strategies guided by genetic profiles.

Conclusion

These results provide valuable insights into the genetic basis of infertility and emphasize the need for further research to develop targeted diagnostic tools and therapies. Understanding the role of miRNA polymorphisms in reproductive health has significant implications for improving outcomes for couples struggling with infertility. By elucidating the genetic factors contributing to infertility, this study paves the way for personalized approaches to diagnosis and treatment, ultimately enhancing reproductive care.

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.