Role of miRNA polymorphisms on male and female infertility and recurrent implantation failure

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-04-02 DOI:10.1111/jog.16281

Reza Alibakhshi, Masoud Soleimani, Kheirollah Yari, Amir Ali Kalhori, Mohsen Karami, Mohammad Reza Kalhori

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引用次数: 0

Abstract

Purpose

MiRNAs regulate gene expression, impacting reproductive health, such as infertility and implantation failure. This study investigated the association between miRNA polymorphisms and male infertility (azoospermia, oligospermia), female infertility (endometriosis), and recurrent implantation failure in IVF.

Methods

In order to find relevant articles, a search was conducted in PubMed, WOS, Scopus, and the Cochrane Library databases using Mesh terms and Entry terms with the keywords (miRNA OR microRNA polymorphism) AND (abortion OR miscarriage OR infertility OR sterility OR pregnancy loss OR implantation failure).

Results

The study revealed miRNA polymorphisms linked to a higher risk of male and female infertility and repeated implantation failure in IVF. These results underscore the significance of genetic variations in miRNAs in developing reproductive issues and the promise of personalized treatment strategies guided by genetic profiles.

Conclusion

These results provide valuable insights into the genetic basis of infertility and emphasize the need for further research to develop targeted diagnostic tools and therapies. Understanding the role of miRNA polymorphisms in reproductive health has significant implications for improving outcomes for couples struggling with infertility. By elucidating the genetic factors contributing to infertility, this study paves the way for personalized approaches to diagnosis and treatment, ultimately enhancing reproductive care.

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miRNA多态性在男性和女性不育和反复植入失败中的作用

目的MiRNAs调控基因表达，影响生殖健康，如不孕不育和着床失败。本研究探讨了miRNA多态性与男性不育症（无精子症、少精子症）、女性不育症（子宫内膜异位症）和IVF中反复植入失败的关系。方法在PubMed、WOS、Scopus和Cochrane Library数据库中检索相关文献，检索关键词为miRNA或microRNA多态性（microRNA OR microRNA polymorphism）和abortion OR miscarriage OR infertility OR sterility OR pregnancy loss OR着植物失败（implantation failure）。结果该研究揭示了miRNA多态性与男性和女性不孕不育和体外受精反复植入失败的高风险相关。这些结果强调了mirna遗传变异在发展生殖问题中的重要性，以及由遗传谱指导的个性化治疗策略的前景。结论这些结果为不孕症的遗传基础提供了有价值的见解，并强调了进一步研究开发有针对性的诊断工具和治疗方法的必要性。了解miRNA多态性在生殖健康中的作用对改善不孕夫妇的结局具有重要意义。通过阐明导致不孕症的遗传因素，本研究为个性化的诊断和治疗方法铺平了道路，最终提高生殖保健。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.