Phytomediated Chitosan-Modified TiO2 NPs for Enhanced Photocatalytic and Potential Application for Breast Cancer Therapy

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2025-04-03 DOI:10.1002/bio.70162

Ankush Chauhan, Rajasekaran Subbarayan, Karthikeyan Ravi, Ritesh Verma, Subha Krishna Rao, Dinesh Murugan Girija, Chandrasekaran Gopalakrishnan, Garima Rana

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Abstract

This work investigates the structural, photocatalytic, and biological properties of Juglans regia leaves extract mediated chitosan-modified TiO₂ nanoparticles (NPs) and Juglans regia mediated TiO₂ NPs. The structural and morphological analysis conducted using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and FTIR revealed that synthesizing the TiO₂ NPs using both chitosan and Juglans regia leaves extract results in lower particle size and less agglomeration in comparison to TiO₂ NPs synthesized using only Juglans regia leaves extract. The photocatalytic activity for the degradation of Rhodamine B using phytomediated chitosan-modified TiO₂ NPs has a remarkable degradation efficacy of 95.07% when subjected to UV–visible light. Further, phytomediated chitosan-modified TiO₂ NPs have ability to reduce the E2 estrogen levels and which inhibits the growth of breast cancer cells (MCF-7) which was confirmed by yeast based XenoScreen XL YES assay, [³H] thymidine incorporation, and apoptosis gene expression (Casp 3 and Casp 9) analysis.

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.