Phytomediated Chitosan-Modified TiO2 NPs for Enhanced Photocatalytic and Potential Application for Breast Cancer Therapy

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2025-04-03 DOI:10.1002/bio.70162

Ankush Chauhan, Rajasekaran Subbarayan, Karthikeyan Ravi, Ritesh Verma, Subha Krishna Rao, Dinesh Murugan Girija, Chandrasekaran Gopalakrishnan, Garima Rana

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Abstract

This work investigates the structural, photocatalytic, and biological properties of Juglans regia leaves extract mediated chitosan-modified TiO₂ nanoparticles (NPs) and Juglans regia mediated TiO₂ NPs. The structural and morphological analysis conducted using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and FTIR revealed that synthesizing the TiO₂ NPs using both chitosan and Juglans regia leaves extract results in lower particle size and less agglomeration in comparison to TiO₂ NPs synthesized using only Juglans regia leaves extract. The photocatalytic activity for the degradation of Rhodamine B using phytomediated chitosan-modified TiO₂ NPs has a remarkable degradation efficacy of 95.07% when subjected to UV–visible light. Further, phytomediated chitosan-modified TiO₂ NPs have ability to reduce the E2 estrogen levels and which inhibits the growth of breast cancer cells (MCF-7) which was confirmed by yeast based XenoScreen XL YES assay, [³H] thymidine incorporation, and apoptosis gene expression (Casp 3 and Casp 9) analysis.

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植物介导壳聚糖修饰的TiO2 NPs增强光催化作用及其在乳腺癌治疗中的潜在应用

本文研究了核桃叶提取物介导的壳聚糖修饰TiO2纳米粒子（NPs）和核桃介导的TiO2纳米粒子的结构、光催化和生物学特性。通过x射线衍射、扫描电镜、透射电镜和红外光谱等对TiO2 NPs进行结构和形态分析，结果表明，壳聚糖和核桃叶提取物合成的TiO2 NPs比只使用核桃叶提取物合成的TiO2 NPs粒径更小，团聚现象更少。在紫外-可见光下，植物介导壳聚糖修饰的TiO2 NPs降解罗丹明B的光催化活性显著，降解效率为95.07%。此外，植物介导的壳聚糖修饰的TiO2 NPs能够降低E2雌激素水平，抑制乳腺癌细胞（MCF-7）的生长，这一点通过酵母基于XenoScreen XL YES实验、[3H]胸腺嘧啶掺入和凋亡基因（Casp 3和Casp 9）分析得到证实。

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.