Assessment of CuFeSe2 ternary nanozymes for multimodal triple negative breast cancer theranostics

IF 13.4 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Chunmei Yang, Lihong Li, Mingdong Li, Yue Shu, Yiping Luo, Didi Gu, Xin Zhu, Jing Chen, Lu Yang, Jian Shu
{"title":"Assessment of CuFeSe2 ternary nanozymes for multimodal triple negative breast cancer theranostics","authors":"Chunmei Yang,&nbsp;Lihong Li,&nbsp;Mingdong Li,&nbsp;Yue Shu,&nbsp;Yiping Luo,&nbsp;Didi Gu,&nbsp;Xin Zhu,&nbsp;Jing Chen,&nbsp;Lu Yang,&nbsp;Jian Shu","doi":"10.1186/s40580-025-00483-4","DOIUrl":null,"url":null,"abstract":"<div><p>Triple negative breast cancer (TNBC) remains a challenge for clinical diagnosis and therapy due to its poor prognosis and high mortality rate. Hence, new methods to achieve TNBC imaging and imaging-guided TNBC therapy are urgently needed. Currently, the combination of chemotherapy with phototherapy/catalytic therapy has become a promising strategy for cancer treatment. Here, multifunctional CuFeSe<sub>2</sub> ternary nanozymes (CuFeSe<sub>2</sub>-AMD3100-Gem nanosheets) were prepared as high-performance nanotheranostic agents for imaging-guided synergistic therapy of TNBC in vitro and in vivo. CuFeSe<sub>2</sub>-AMD3100-Gem nanosheets not only exhibited outstanding CXCR4-targeted capability and superior photothermal properties, but also produced exact chemical cytotoxicity through the loading of the chemotherapy drug Gemcitabine. Specifically, the CuFeSe<sub>2</sub>-AMD3100-Gem nanosheets simultaneously possessed peroxidase-like activities capable of converting endogenous H<sub>2</sub>O<sub>2</sub> to hydroxyl radicals (•OH), which could be significantly enhanced under light irradiation. Furthermore, these nanosheets showed remarkable multimodal imaging ability for magnetic resonance imaging (MRI), computed tomography (CT) and infrared thermography in TNBC tumor-bearing mice (4T1 cells). More importantly, the in vitro and in vivo results verified the significant synergistic anticancer effect of the CuFeSe<sub>2</sub>-AMD3100-Gem nanosheets by combining photothermal therapy and enzyme catalytic therapy with chemotherapy. In conclusion, these advantages demonstrate the powerful potential of CuFeSe<sub>2</sub> ternary nanozymes for imaging-guided synergistic photothermal/catalytic/chemical therapy for TNBC.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00483-4","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Convergence","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1186/s40580-025-00483-4","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Triple negative breast cancer (TNBC) remains a challenge for clinical diagnosis and therapy due to its poor prognosis and high mortality rate. Hence, new methods to achieve TNBC imaging and imaging-guided TNBC therapy are urgently needed. Currently, the combination of chemotherapy with phototherapy/catalytic therapy has become a promising strategy for cancer treatment. Here, multifunctional CuFeSe2 ternary nanozymes (CuFeSe2-AMD3100-Gem nanosheets) were prepared as high-performance nanotheranostic agents for imaging-guided synergistic therapy of TNBC in vitro and in vivo. CuFeSe2-AMD3100-Gem nanosheets not only exhibited outstanding CXCR4-targeted capability and superior photothermal properties, but also produced exact chemical cytotoxicity through the loading of the chemotherapy drug Gemcitabine. Specifically, the CuFeSe2-AMD3100-Gem nanosheets simultaneously possessed peroxidase-like activities capable of converting endogenous H2O2 to hydroxyl radicals (•OH), which could be significantly enhanced under light irradiation. Furthermore, these nanosheets showed remarkable multimodal imaging ability for magnetic resonance imaging (MRI), computed tomography (CT) and infrared thermography in TNBC tumor-bearing mice (4T1 cells). More importantly, the in vitro and in vivo results verified the significant synergistic anticancer effect of the CuFeSe2-AMD3100-Gem nanosheets by combining photothermal therapy and enzyme catalytic therapy with chemotherapy. In conclusion, these advantages demonstrate the powerful potential of CuFeSe2 ternary nanozymes for imaging-guided synergistic photothermal/catalytic/chemical therapy for TNBC.

Graphical Abstract

评估用于多模式三阴性乳腺癌治疗的 CuFeSe2 三元纳米酶
三阴性乳腺癌因其预后差、死亡率高,一直是临床诊断和治疗的挑战。因此,迫切需要新的方法来实现TNBC成像和成像引导下的TNBC治疗。目前,化疗与光疗/催化治疗相结合已成为一种很有前景的癌症治疗策略。本研究制备了多功能CuFeSe2三元纳米酶(CuFeSe2- amd3100 - gem纳米片)作为高性能纳米治疗剂,用于体外和体内成像引导的TNBC协同治疗。CuFeSe2-AMD3100-Gem纳米片不仅具有出色的cxcr4靶向能力和优越的光热性能,而且通过负载化疗药物吉西他滨产生了精确的化学细胞毒性。具体来说,CuFeSe2-AMD3100-Gem纳米片同时具有类似过氧化物酶的活性,能够将内源性H2O2转化为羟基自由基(•OH),并且在光照下可以显著增强。此外,这些纳米片在TNBC荷瘤小鼠(4T1细胞)的磁共振成像(MRI)、计算机断层扫描(CT)和红外热成像中显示出显著的多模态成像能力。更重要的是,体外和体内实验结果验证了光热疗法和酶催化疗法联合化疗对CuFeSe2-AMD3100-Gem纳米片具有显著的协同抗癌作用。综上所述,这些优势显示了CuFeSe2三元纳米酶在TNBC成像引导协同光热/催化/化学治疗中的强大潜力。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Nano Convergence
Nano Convergence Engineering-General Engineering
CiteScore
15.90
自引率
2.60%
发文量
50
审稿时长
13 weeks
期刊介绍: Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects. Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信