{"title":"Terpenoids with Antiangiogenic Activity from Formosan Soft Coral Caementabunda hypotentaculata","authors":"Hsin Huang, Chen-Yu Yang, Shih-Wei Wang, Limbadri Salendra, Shu-Rong Chen, Tzi-Yi Ke, Yu-Liang Yang, Yu-Chi Lin, Yuan-Bin Cheng","doi":"10.1007/s10126-025-10452-x","DOIUrl":null,"url":null,"abstract":"<div><p>Soft corals of the genus <i>Caementabunda</i> (synonym <i>Cespitularia</i>) were reported to possess terpenoids with various carbon skeletons. In this research, samples of <i>C. hypotentaculata</i> were collected before and after spawning (in May and August) to compare their secondary metabolites. With the aid of LC–MS/MS molecule networking, a series of unknown verticillane-type diterpenoids were targeted. After repeated column chromatography, five new verticillane-type diterpenoids (<b>1</b>‒<b>5</b>) and one new eudesmanolide-type sesquiterpenoid (<b>6</b>), together with twenty-four known compounds (<b>7</b>‒<b>30</b>), were identified from the Formosan soft coral <i>C. hypotentaculata</i>. Their structures were determined by UV, IR, MS, and NMR analyses, together with the biogenetic considerations of terpenoids. Our pharmacological study showed that the ethanol extract of <i>C. hypotentaculata</i> exhibited antiangiogenic potential against human endothelial progenitor cells. Among all isolated compounds, compound <b>30</b> demonstrated a moderate antiangiogenic effect with an IC<sub>50</sub> value of 29.0 ± 0.6 μM.</p></div>","PeriodicalId":690,"journal":{"name":"Marine Biotechnology","volume":"27 2","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Marine Biotechnology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s10126-025-10452-x","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Soft corals of the genus Caementabunda (synonym Cespitularia) were reported to possess terpenoids with various carbon skeletons. In this research, samples of C. hypotentaculata were collected before and after spawning (in May and August) to compare their secondary metabolites. With the aid of LC–MS/MS molecule networking, a series of unknown verticillane-type diterpenoids were targeted. After repeated column chromatography, five new verticillane-type diterpenoids (1‒5) and one new eudesmanolide-type sesquiterpenoid (6), together with twenty-four known compounds (7‒30), were identified from the Formosan soft coral C. hypotentaculata. Their structures were determined by UV, IR, MS, and NMR analyses, together with the biogenetic considerations of terpenoids. Our pharmacological study showed that the ethanol extract of C. hypotentaculata exhibited antiangiogenic potential against human endothelial progenitor cells. Among all isolated compounds, compound 30 demonstrated a moderate antiangiogenic effect with an IC50 value of 29.0 ± 0.6 μM.
期刊介绍：
Marine Biotechnology welcomes high-quality research papers presenting novel data on the biotechnology of aquatic organisms. The journal publishes high quality papers in the areas of molecular biology, genomics, proteomics, cell biology, and biochemistry, and particularly encourages submissions of papers related to genome biology such as linkage mapping, large-scale gene discoveries, QTL analysis, physical mapping, and comparative and functional genome analysis. Papers on technological development and marine natural products should demonstrate innovation and novel applications.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
