Efficacy and Safety of triplet versus doublet regimens in patients with multiple myeloma: A systematic review and meta-analysis

IF 2.5 4区医学 Q3 ONCOLOGY

Current Problems in Cancer Pub Date : 2025-04-03 DOI:10.1016/j.currproblcancer.2025.101202

Zilu Meng , Hanxue Zheng , Yanhong Li , Jun Bai , Liansheng Zhang , Lijuan Li

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引用次数: 0

Abstract

Background

The efficacy and safety of various therapies for multiple myeloma (MM) remain a subject of ongoing debate, with inconsistent findings. This meta-analysis aimed to compare the efficacy and safety of triplet versus doublet regimens in the management of MM. This study followed the guidelines delineated in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 statement, with our protocol duly registered in PROSPERO (CRD42024527903).

Methods

An exhaustive literature search was performed across four databases, PubMed, EMBASE, Web of Science, and Cochrane Library, from their commencement to March 5, 2024. Data on overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), adverse events (AEs), and grade ≥ 3 AEs were synthesized using either random-effects or fixed-effects models.

Results

This analysis considered 29 studies, which cover approximately 11,230 MM patients in total. Triplet regimens were found to yield better PFS and OS for MM patients as compared to the doublet regimens. Although the incidence of serious AEs was higher under the triplet regimens, with pooled RRs of grade ≥ 3 AEs reaching 1.13. Besides, subgroup analysis demonstrated that patients with relapsed/refractory multiple myeloma (RRMM) tended to have better PFS and OS under triple therapy, in contrast to newly diagnosed multiple myeloma (NDMM) and older adults, who experienced little to no significant impact.

Conclusions

Triplet regimens demonstrate superior PFS and OS compared to doublet regimens in MM patients, but also have a higher likelihood of causing AEs of grade 3 or 4.

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来源期刊

Current Problems in Cancer 医学-肿瘤学

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

15 days

期刊介绍： Current Problems in Cancer seeks to promote and disseminate innovative, transformative, and impactful data on patient-oriented cancer research and clinical care. Specifically, the journal''s scope is focused on reporting the results of well-designed cancer studies that influence/alter practice or identify new directions in clinical cancer research. These studies can include novel therapeutic approaches, new strategies for early diagnosis, cancer clinical trials, and supportive care, among others. Papers that focus solely on laboratory-based or basic science research are discouraged. The journal''s format also allows, on occasion, for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering articles that present dynamic material that influences the oncology field.