Analysis of clinical characteristics and prognosis of childhood functional neurological disorder: Identifying key factors of prognosis and optimizing clinical management

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-04-01 DOI:10.1016/j.jpsychores.2025.112120

Anqi Wang , Xiaowen Yang , Yu Tian , Hua Yang , Rong Luo

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引用次数: 0

Abstract

Background

To explore and analyze the clinical characteristics of childhood functional neurological disorder (FND) and identify key factors influencing the prognosis to optimize clinical practice.

Method

In this retrospective study, clinical data of children with FND who visited the Department of Pediatric Neurology of West China Second Hospital of Sichuan University between March 2020 and March 2023 were collected to analyze their clinical characteristics and prognosis. And 173 patients completed follow-up one year after diagnosis. Logistic regression was used to analyze factors associated with clinical prognosis.

Results

Among the 248 patients, with a median age of 10 years (IQR 9–12), 60.5 % were male and 39.5 % were female. The most common symptoms were weakness or paralysis and non-epileptic seizures. 11.2 % combined with psychiatric disorders. Half of the patients had experienced previous stressors, including personal (40.3 %), family (22.6 %), and school factors (21.0 %). The average follow-up time was 488.7 ± 295.5 days. The overall prognosis was good, with clinical symptom remission in 75.1 % of cases. Logistic regression revealed that both the duration of symptoms and comorbid psychiatric disorders were negatively associated with a good prognosis.

Conclusion

The clinical characteristics of children with FND may be associated with socio-cultural background factors and psychological factors. Symptom duration and comorbid psychiatric disorders are important factors influencing prognosis.

查看原文本刊更多论文

背景探讨和分析儿童功能性神经障碍性疾病（FND）的临床特点，找出影响预后的关键因素，以优化临床实践。方法在这项回顾性研究中，收集了2020年3月至2023年3月期间在四川大学华西第二医院小儿神经内科就诊的FND患儿的临床资料，分析其临床特点和预后。173名患者在确诊一年后完成了随访。结果 248 例患者中，男性占 60.5%，女性占 39.5%，中位年龄为 10 岁（IQR 9-12）。最常见的症状是虚弱或瘫痪以及非癫痫性发作。11.2%的患者合并有精神障碍。半数患者曾经历过压力，包括个人因素（40.3%）、家庭因素（22.6%）和学校因素（21.0%）。平均随访时间为 488.7 ± 295.5 天。总体预后良好，75.1%的病例临床症状缓解。Logistic 回归显示，症状持续时间和合并精神障碍与预后良好呈负相关。症状持续时间和合并精神障碍是影响预后的重要因素。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.