LUDICAS: sexual dysfunction in patients with lung cancer, a multicenter cross-sectional study☆

IF 7.1 2区医学 Q1 ONCOLOGY

ESMO Open Pub Date : 2025-04-01 DOI:10.1016/j.esmoop.2025.104539

A.V. Ospina-Serrano , A. Collazo-Lorduy , E. Azkona-Uribelarrea , P. Guillen-Sentís , F. Aparisi , R. López , P. Cruz , A. Valdivia , P. Cordeiro , A. Olivares-Hernández , M. Blanco , R. Casas-Cornejo , E. Carcereny , M. Dómine , M. Antoñanzas , A. Blasco-Cordellat , D. Peralta , M. Sereno , A. Cardeña-Gutiérrez , R. Romão , M. Provencio-Pulla

{"title":"LUDICAS: sexual dysfunction in patients with lung cancer, a multicenter cross-sectional study☆","authors":"A.V. Ospina-Serrano , A. Collazo-Lorduy , E. Azkona-Uribelarrea , P. Guillen-Sentís , F. Aparisi , R. López , P. Cruz , A. Valdivia , P. Cordeiro , A. Olivares-Hernández , M. Blanco , R. Casas-Cornejo , E. Carcereny , M. Dómine , M. Antoñanzas , A. Blasco-Cordellat , D. Peralta , M. Sereno , A. Cardeña-Gutiérrez , R. Romão , M. Provencio-Pulla","doi":"10.1016/j.esmoop.2025.104539","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Patients with lung cancer may suffer from sexual dysfunction (SD) related to oncological treatment. This is an under-recognized condition among clinicians. The aim of this study was to describe the prevalence of SD in a multicenter cohort of patients.</div></div><div><h3>Patients and methods</h3><div>This multicenter, cross-sectional, observational study was conducted between July 2023 and February 2024. Sexual function was assessed by patient-reported outcome (PRO) system using sex-specific questionnaire. Descriptive analysis and evaluation of differences between categorical variables were carried out. Associations between clinical characteristics and SD were assessed by logistic regression.</div></div><div><h3>Results</h3><div>Four hundred and forty-eight patients from 24 hospitals in Spain, Colombia, Argentina, and Portugal were included. Of these, 277 (61.83%) were male and 365 (81.48%) had metastatic disease. Two hundred and eighty-four patients (63.39%) reported the onset of SD following the initiation of oncological treatment. Males and females reported a high frequency of severe impairment of sexual response phases, which was twice as high in females (<em>P</em> <em>=</em> 0.001). Female sex was a factor for severe impairment of desire, arousal, and orgasm [odds ratio (OR) 3.72, 95% confidence interval (CI) 2.48-5.60, <em>P</em> <em>=</em> 0.001] and decreased sexual activity (OR 1.98, 95% CI:1.17-3.19, <em>P</em> = 0.01), in addition to age over 65 years (OR 3.86, 95% CI 1.01-15.25, <em>P</em> <em>=</em> 0.004) and high educational level (OR 0.29, 95% CI 0.09-0.94, <em>P</em> <em>=</em> 0.0040). Patients from Portugal and Latin America were more likely to report dissatisfaction with sexual activity (OR 3.75, 95% CI 1.06-13.22, <em>P</em> <em>=</em> 0.0039). Female sex (OR 3.53, 95% CI 1.88-6.6, <em>P</em> 0.001), smoking history (OR 1.77, 95% CI 1.01-4.01, <em>P</em> <em>=</em> 0.04), and obesity (OR 1.70 95% CI 1.01-3.16, <em>P</em> <em>=</em> 0.05) were associated with global sexual dissatisfaction.</div></div><div><h3>Conclusions</h3><div>Our patients with lung cancer had a high prevalence of SD after initiation of oncological treatment. There was remarkable sex disparity in the frequency and severity of this disorder as well as an important influence of sociocultural factors in the clinical presentation.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 4","pages":"Article 104539"},"PeriodicalIF":7.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ESMO Open","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2059702925004089","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Patients with lung cancer may suffer from sexual dysfunction (SD) related to oncological treatment. This is an under-recognized condition among clinicians. The aim of this study was to describe the prevalence of SD in a multicenter cohort of patients.

Patients and methods

This multicenter, cross-sectional, observational study was conducted between July 2023 and February 2024. Sexual function was assessed by patient-reported outcome (PRO) system using sex-specific questionnaire. Descriptive analysis and evaluation of differences between categorical variables were carried out. Associations between clinical characteristics and SD were assessed by logistic regression.

Results

Four hundred and forty-eight patients from 24 hospitals in Spain, Colombia, Argentina, and Portugal were included. Of these, 277 (61.83%) were male and 365 (81.48%) had metastatic disease. Two hundred and eighty-four patients (63.39%) reported the onset of SD following the initiation of oncological treatment. Males and females reported a high frequency of severe impairment of sexual response phases, which was twice as high in females (P = 0.001). Female sex was a factor for severe impairment of desire, arousal, and orgasm [odds ratio (OR) 3.72, 95% confidence interval (CI) 2.48-5.60, P = 0.001] and decreased sexual activity (OR 1.98, 95% CI:1.17-3.19, P = 0.01), in addition to age over 65 years (OR 3.86, 95% CI 1.01-15.25, P = 0.004) and high educational level (OR 0.29, 95% CI 0.09-0.94, P = 0.0040). Patients from Portugal and Latin America were more likely to report dissatisfaction with sexual activity (OR 3.75, 95% CI 1.06-13.22, P = 0.0039). Female sex (OR 3.53, 95% CI 1.88-6.6, P 0.001), smoking history (OR 1.77, 95% CI 1.01-4.01, P = 0.04), and obesity (OR 1.70 95% CI 1.01-3.16, P = 0.05) were associated with global sexual dissatisfaction.

Conclusions

Our patients with lung cancer had a high prevalence of SD after initiation of oncological treatment. There was remarkable sex disparity in the frequency and severity of this disorder as well as an important influence of sociocultural factors in the clinical presentation.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

ESMO Open Medicine-Oncology

CiteScore

11.70

自引率

2.70%

发文量

255

审稿时长

10 weeks

期刊介绍： ESMO Open is the online-only, open access journal of the European Society for Medical Oncology (ESMO). It is a peer-reviewed publication dedicated to sharing high-quality medical research and educational materials from various fields of oncology. The journal specifically focuses on showcasing innovative clinical and translational cancer research. ESMO Open aims to publish a wide range of research articles covering all aspects of oncology, including experimental studies, translational research, diagnostic advancements, and therapeutic approaches. The content of the journal includes original research articles, insightful reviews, thought-provoking editorials, and correspondence. Moreover, the journal warmly welcomes the submission of phase I trials and meta-analyses. It also showcases reviews from significant ESMO conferences and meetings, as well as publishes important position statements on behalf of ESMO. Overall, ESMO Open offers a platform for scientists, clinicians, and researchers in the field of oncology to share their valuable insights and contribute to advancing the understanding and treatment of cancer. The journal serves as a source of up-to-date information and fosters collaboration within the oncology community.