Relationships between clinician adherence to guideline-recommended treatment and memory function in patients with schizophrenia

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-03-27 DOI:10.1016/j.jpsychires.2025.03.054

Yasushi Kawamata , Kazutaka Ohi , Satsuki Ito , Naomi Hasegawa , Yuka Yasuda , Michiko Fujimoto , Hidenaga Yamamori , Kentaro Fukumoto , Fumitoshi Kodaka , Junya Matsumoto , Norio Yasui-Furukori , Ryota Hashimoto

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引用次数: 0

Abstract

Background

Memory function impairment is severe in patients with schizophrenia, but improving memory function remains challenging. The use of benzodiazepines and anticholinergics, which are not recommended by pharmacological therapy guidelines for schizophrenia, has been associated with worsened cognitive function. However, it remains unclear whether better adherence by psychiatrists to pharmacological therapy guidelines for schizophrenia is associated with improved memory function. Therefore, we investigated the relationship between psychiatrists’ adherence and memory function in patients with schizophrenia.

Methods

To evaluate the associations between psychiatrists' adherence to pharmacological therapy guidelines and memory function, we utilized the Individual Fitness Score (IFS), which includes multiple quality indicators, to assess each psychiatrist's adherence to these guidelines in treating each patient. Memory function was measured using the Wechsler Memory Scale-Revised in a total of 351 patients, including 40 patients with treatment-resistant schizophrenia (TRS) and 311 patients with non-TRS.

Results

We found that psychiatrist adherence was significantly positively correlated with verbal memory (β = 0.145, p = 6.45 × 10⁻³), attention/concentration (β = 0.138, p = 0.010), and delayed recall (β = 0.167, p = 1.57 × 10⁻³) in all patients with schizophrenia. Additionally, a nominal positive correlation was observed with visual memory (β = 0.124, p = 0.019). In non-TRS patients, the adherence of psychiatrists was significantly positively correlated with delayed recall (β = 0.166, p = 3.17 × 10⁻³) and nominally positively correlated with verbal memory (β = 0.141, p = 0.013) and attention/concentration (β = 0.114, p = 0.044) functions. In contrast, no significant associations were observed between the psychiatrists’ adherence and any memory functions in patients with TRS.

Conclusions

These findings suggest that enhancing guideline education for psychiatrists might improve cognitive impairments in patients with schizophrenia.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;