The simplified depth-predicting score outperforms the depth-predicting score for predicting the depth of invasion in differentiated early gastric cancer patients among nonexpert endoscopists

Gastroenterología y Hepatología (English Edition) Pub Date : 2025-04-01 DOI:10.1016/j.gastre.2025.502265

Lulu Zeng , Hui Li , Tian Huang , Yuting Heng , Jun Liu , Xiangpeng Hu

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Abstract

Aim

Endoscopists utilize depth-predicting score (DPS) and simplified depth-predicting score (S-DPS) to predict the invasion depth of early gastric cancer based on conventional white-light endoscopic features. The effectiveness of these scores has not been fully elucidated among nonexpert endoscopists. This study aimed to compare the ability of DPS and S-DPS to predict invasion depth of differentiated early gastric cancers by nonexpert endoscopists.

Participants and methods

We collected subitem scores of DPS and S-DPS from 19 nonexpert endoscopists for early gastric cancer conventional white-light endoscopy images in the test dataset to predict the invasion depth of the early gastric cancer conventional white-light endoscopy images. Accuracy, specificity, overdiagnosis rate, and underdiagnosis rate were subsequently calculated using the histological invasion depth as the gold standard.

Results

Using 3 as the cutoff line, the overall S-DPS diagnostic accuracy for invasion depth was significantly greater than that of DPS [73.86% (69.32%, 75.00%) vs. 67.05% (62.50%, 71.59%), p = 0.005]. The overall S-DPS overdiagnosis rate was significantly lower than that of DPS [7.58% (3.03%, 13.64%) vs. 28.79% (18.18%, 37.88%), p = 0.000]. The overall S-DPS under-diagnosed rate was significantly higher than that of DPS [86.36% (68.18%, 90.91%) vs. 45.45% (31.82%, 59.09%), p = 0.000]. The specificity of the S-DPS was significantly greater than that of DPS [92.42% (86.36%, 96.97%) vs. 71.21% (62.12%, 81.82%), p = 0.000].

Conclusion

The diagnostic accuracy of the S-DPS was greater than that of the DPS among nonexpert endoscopists. Furthermore, S-DPS is simpler than other methods, making it more conducive to clinical application for nonexpert endoscopists.

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简化深度预测评分在非专业内镜医师中预测分化早期胃癌患者浸润深度方面优于深度预测评分

内镜医师基于常规白光内镜特征，采用深度预测评分（depth- prediction score， DPS）和简化深度预测评分（simplified depth- prediction score, S-DPS）预测早期胃癌的浸润深度。这些评分的有效性尚未在非专业内窥镜医师中得到充分阐明。本研究旨在比较非专业内镜医师使用DPS和S-DPS预测分化早期胃癌侵袭深度的能力。研究对象与方法收集19名早期胃癌常规白光内镜非专业内镜医师的DPS和S-DPS分项评分，用于预测早期胃癌常规白光内镜图像的侵袭深度。随后以组织学浸润深度为金标准计算准确性、特异性、过诊率和漏诊率。结果以3为临界线，S-DPS对侵深的总体诊断准确率显著高于DPS[73.86%（69.32%, 75.00%）比67.05% (62.50%,71.59%),p = 0.005]。总体S-DPS超诊断率显著低于DPS组[7.58% (3.03%,13.64%)vs. 28.79% (18.18%, 37.88%), p = 0.000]。总体S-DPS漏诊率显著高于DPS[86.36%（68.18%, 90.91%）比45.45% (31.82%,59.09%),p = 0.000]。S-DPS的特异性显著高于DPS[92.42%（86.36%, 96.97%）比71.21% (62.12%,81.82%),p = 0.000]。结论在非专业内镜医师中，S-DPS的诊断准确率高于DPS。此外，S-DPS比其他方法更简单，更有利于非专业内镜医师的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gastroenterología y Hepatología (English Edition)

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