Alpha to omega for molybdenum disulfide (MoS2)-based antibacterial nanomaterials

IF 5.3 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics Pub Date : 2025-03-30 DOI:10.1016/j.ijpharm.2025.125531

Barlina Konwar , Sukrit Kashyap , Srimathi Raghavan, Kwang-sun Kim

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Abstract

Addressing antimicrobial resistance is crucial in microbial studies, especially in creating alternative drug candidates vital for protecting human health from multidrug-resistant microorganisms. Nanomaterials (NMs) have emerged as a potential solution, drawing considerable interest owing to their unique structural and functional characteristics that render them effective against microbes. Two-dimensional NMs, particularly those based on molybdenum disulfide (MoS₂), have shown promise as antimicrobial agents owing to their exceptional properties. Although research has advanced in exploring and applying MoS₂ NMs for antimicrobial purposes, strategies for optimizing and modifying their use as antimicrobial agents remain in their early developmental stages. This review presents a comprehensive overview of the current MoS₂ NMs for antimicrobial applications, including their synthesis, properties, optimization techniques, and modifications, as well as their mechanisms of action. This review also addresses the limitations of the individual materials and proposes future directions for overcoming these challenges. This compilation serves as an invaluable resource for scientists working on the development of targeted antimicrobial agents.

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二硫化钼（MoS2）基抗菌纳米材料的α到ω

解决抗菌素耐药性问题在微生物研究中至关重要，特别是在开发替代候选药物方面，这对保护人类健康免受多重耐药微生物的侵害至关重要。纳米材料（NMs）已经成为一种潜在的解决方案，由于其独特的结构和功能特征，使其能够有效地对抗微生物，引起了相当大的兴趣。二维NMs，特别是基于二硫化钼（MoS2）的NMs，由于其特殊的性能，已经显示出作为抗菌剂的前景。尽管在探索和应用二硫化钼纳米粒抗菌方面取得了进展，但优化和修饰其抗菌用途的策略仍处于早期发展阶段。本文综述了目前用于抗菌的二硫化钼纳米管的合成、性能、优化技术、改性及其作用机制。本综述还讨论了单个材料的局限性，并提出了克服这些挑战的未来方向。该汇编为致力于开发靶向抗菌剂的科学家提供了宝贵的资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmaceutics 医学-药学

CiteScore

10.70

自引率

8.60%

发文量

951

审稿时长

72 days

期刊介绍： The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.