Facilitating cognitive neuroscience research with 80-sensor optically pumped magnetometer magnetoencephalography (OPM-MEG)

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-04-01 DOI:10.1016/j.neuroimage.2025.121182

Wei Xu , Pan Liao , Miao Cao , David J. White , Bingjiang Lyu , Jia-Hong Gao

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引用次数: 0

Abstract

Recent advancements in optically pumped magnetometer magnetoencephalography (OPM-MEG) make it a promising alternative to conventional SQUID-MEG systems. Nonetheless, as reported in the literature, current OPM-MEG systems are often constrained by a limited number of sampling points, which restricts their capability to match the full-head coverage offered by SQUID-MEG systems. Additionally, whether OPM-MEG can deliver results comparable to SQUID-MEG in practical cognitive neuroscience applications remains largely unexplored. In this study, we introduce a high-density, full-head coverage OPM-MEG system with 80 sensors and systematically compare the performance of OPM-MEG and SQUID-MEG, from sensor- to source-level analysis, across various classic cognitive tasks. Our results demonstrate that visual and auditory evoked fields captured using OPM-MEG align closely with those obtained from SQUID-MEG. Furthermore, steady-state visual evoked field and finger-tapping-induced beta power change recorded with OPM-MEG are accurately localized to corresponding brain regions, with activation centers highly congruent to those observed with SQUID-MEG. For resting-state recordings, the two modalities exhibit similar power distributions, functional connectomes, and microstate clusters. These findings indicate that the 80-sensor OPM-MEG system provides spatial and temporal characteristics comparable to those of traditional SQUID-MEG. Thus, our study offers empirical evidence supporting the efficacy of high-density OPM-MEG and suggests that OPM-MEG, with dense sampling capability, represents a compelling alternative to conventional SQUID-MEG, facilitating further exploration of human cognition.

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80传感器光泵磁强计脑磁图（OPM-MEG）促进认知神经科学研究

光泵磁强计脑磁图（OPM-MEG）的最新进展使其成为传统SQUID-MEG系统的一个有希望的替代方案。然而，正如文献报道的那样，目前的OPM-MEG系统经常受到采样点数量有限的限制，这限制了它们与SQUID-MEG系统提供的全头部覆盖相匹配的能力。此外，在实际的认知神经科学应用中，OPM-MEG是否能提供与SQUID-MEG相当的结果仍未被探索。在本研究中，我们引入了一个包含80个传感器的高密度、全头部覆盖的OPM-MEG系统，并系统地比较了OPM-MEG和SQUID-MEG在各种经典认知任务中的性能，从传感器到源级分析。我们的研究结果表明，OPM-MEG捕获的视觉和听觉诱发场与SQUID-MEG获得的诱发场密切一致。此外，OPM-MEG记录的稳态视觉诱发场和手指轻敲诱发的β功率变化准确定位于相应的脑区，其激活中心与SQUID-MEG观察到的高度一致。对于静息状态记录，两种模式表现出相似的功率分布、功能连接体和微状态簇。这些结果表明，80个传感器的OPM-MEG系统具有与传统SQUID-MEG相当的时空特征。因此，我们的研究提供了支持高密度OPM-MEG有效性的经验证据，并表明具有密集采样能力的OPM-MEG代表了传统SQUID-MEG的令人信服的替代方案，有助于进一步探索人类认知。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.